Prescott's Microbiology
Prescott's Microbiology
10th Edition
ISBN: 9781259281594
Author: Joanne Willey, Linda Sherwood Adjunt Professor Lecturer, Christopher J. Woolverton Professor
Publisher: McGraw-Hill Education
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Chapter 18.5, Problem 1MI

Chapter 18.5, Problem 1MI, Figure 18.12 Metabolic Pathways and Transport Systems of Treponema pallidum. This depicts T.

Figure 18.12 Metabolic Pathways and Transport Systems of Treponema pallidum. This depicts T. pallidum metabolism as deduced from genome annotation. Note the limited biosynthetic capabilities and extensive array of transporters. Although glycolysis is present, the TCA cycle and respiratory electron transport are lacking. Question marks indicate where uncertainties exist or expected activities have not been found.

Based on this genomic reconstruction, can you determine if T. pallidum has a respiratory or fermentative metabolism?

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Yarrowia lipolytica(Yl) is a non-conventional yeast that diverged from baker’s yeast, Saccharomyces cerevisiae(Sc), early in evolutionary history. The regulation of glycolytic enzymes in Yl differs from that of Sc. The figures below show how PFK activity is affected by fructose-2,6-bisphosphate and phosphoenolpyruvate. Based on these data, which molecule is the major regulator of PFK activity in each species?
Yarrowia lipolytica(Yl) is a non-conventional yeast that diverged from baker’s yeast, Saccharomyces cerevisiae(Sc), early in evolutionary history. The regulation of glycolytic enzymes in Yl differs from that of Sc. The data below pertain to regulation of phosphofructokinase 1 (PFK). Data for Yl is shown with black circles and data for Sc is shown with white circles.  Pfk for both species is a homo-octomer (eight identical subunits). Given the data below, which species is more likely to be susceptible to allosteric modification? Briefly explain.
Why are there reversible steps in the glycolytic pathway? Explain why they all be could not be irreversible?

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Prescott's Microbiology

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