Genetics: From Genes To Genomes (6th International Edition)
6th Edition
ISBN: 9781260041217
Author: Leland Hartwell Dr., ? Michael L. Goldberg Professor Dr., ? Janice Fischer, ? Leroy Hood Dr.
Publisher: Mcgraw-Hill
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Textbook Question
Chapter 19, Problem 34P
The Drosophila even-skipped (eve) gene has four different enhancers that control its transcription in a pattern of seven stripes. (One of them—the stripe 2 enhancer—is shown in Fig. 19.23c.)
| a. | Why is the stripe 2 enhancer active only in cells corresponding to stripe 2? |
| b. | The other three enhancers each work in the cells corresponding to two different (nonadjacent) stripes. How is this possible? |
| c. | Secondary pair-rule genes like ftz have only one enhancer that is active in all seven stripes. How is this possible? Describe an experiment that would have led scientists to this conclusion. |
| d. | Would you expect the segment polarity gene engrailed to have two enhancers or fourteen enhancers, one active in each stripe? |
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FIGURE 4.6. Comparison of Northern blots with DNA microarray
data. a) Results from four individual Northern blots examining four different
genes and measuring mRNA production over time, as indicated. b) Results
from a series of microarrays for the same four genes of interest. Note the color
scale on the bottom of b), where bright green indicates a 20-fold repression
and bright red indicates a 20-fold induction. Black indicates no change in
transcription (i.e., the merged microarray spot would have appeared yellow).
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FIGURE 4.7 Transcriptional response of three genes
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1)A. how do you read a sequence of DNA (template or non-template strand) to convert it
an mRNA sequence and to a protein?
B.How does chromatin remodeling regulate gene transcription?
C. What are the major differences between gene expression in bacteria and eukaryotes
D. How are non-coding regions involved in gene transcription?
E. Explain how eukaryotic genes sometimes produce multiple protein products?
Please answer
A mutation within an enhancer sequence regulating the expression of the ABC1 gene was discovered. Specifically, the mutation was associated with decreased expression of ABC1 in skeletal muscle. In a heterozygous individual carrying a mutant enhancer and a wild type enhancer, which allele(s) would be affected by the mutant enhancer and why?
Chapter 19 Solutions
Genetics: From Genes To Genomes (6th International Edition)
Ch. 19 - Match each of the terms in the left column to the...Ch. 19 - a. If you were interested in the role of a...Ch. 19 - Early C. elegans embryos display mosaic...Ch. 19 - Hypomorphic mutations in the wingless gene of...Ch. 19 - Prob. 5PCh. 19 - In 1932, H. J. Muller suggested a genetic test to...Ch. 19 - a. Explain how you could use worms transformed...Ch. 19 - Suppose you want to determine whether a particular...Ch. 19 - Sevenless is an unusual receptor protein in that...Ch. 19 - Suppose that you generated flies containing a...
Ch. 19 - Drosophila researchers have collected many strains...Ch. 19 - As an alternative to random mutagenesis,...Ch. 19 - A C. elegans nematode gene called par-1 helps to...Ch. 19 - The molecular identity of the fruit fly rugose...Ch. 19 - To determine the focus of action of boss,...Ch. 19 - Suppose a particular gene is required for early...Ch. 19 - Researchers have exploited Minute mutations in...Ch. 19 - Some ts alleles are temperature sensitive during...Ch. 19 - The following figure shows the temperature-shift...Ch. 19 - A temperature-sensitive allele of the gene...Ch. 19 - Hypomorphic alleles of a pleiotropic gene...Ch. 19 - In addition to the maternal effect genes that...Ch. 19 - The yan gene encodes a transcription factor that...Ch. 19 - Recall from Chapter 17 that in Drosophila, sex...Ch. 19 - a. Explain the difference between maternal...Ch. 19 - In the 1920s, Arthur Boycott, working with the...Ch. 19 - The Drosophila mutant screen shown on the...Ch. 19 - Some genes are required both zygotically and...Ch. 19 - How would a human with a mutation in a maternal...Ch. 19 - One important demonstration that Bicoid is an...Ch. 19 - The hunchback gene contains a 5 transcriptional...Ch. 19 - In flies developing from eggs laid by a...Ch. 19 - Wild-type embryos and mutant embryos lacking the...Ch. 19 - The Drosophila even-skipped eve gene has four...Ch. 19 - In Drosophila with loss-of-function mutations...Ch. 19 - It is crucial to the development of Drosophila...Ch. 19 - In the plant Arabidopsis thaliana, every flower is...
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