Interpretation: The synthesis of given carboxylic acid from
Concept introduction: The replacement or substitution of one functional group with another different functional group in any
Grignard reagent is prepared by the reaction of alkyl or aryl bromide with magnesium metal in the presence of ether. The reaction of Grignard reagent with an
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Loose Leaf for Organic Chemistry
- Varenicline (trade name Chantix) is a drug used to help smokers quit their habit. (a) Which N atom in varenicline is most basic? Explain your choice. (b) What product is formed when varenicline is treated with HCl?arrow_forwardDevise a synthesis of compound A from the given starting materials. You may use any other inorganic reagents or organic alcohols. A was used to prepare aliskiren, a drug used to treat hypertension (see also Problem 5.7).arrow_forwardPart A: Draw the product of the reaction of propylamine with water Part B: Draw the product of the neutralization of propylamine with HBr Part C: Draw the product of the reaction of N-methylaniline with waterarrow_forward
- Varenicline (trade name Chantix) is a drug used to help smokers quittheir habit. (a) Which N atom in varenicline is most basic? Explain your choice. (b) What product is formed when varenicline is treated with HCl?arrow_forwardDraw a stepwise mechanism for the following reaction, a key step in the synthesis of conivaptan (trade name Vaprisol), a drug used in the treatment of low sodium levels.arrow_forwardShown compound is Compound F. Draw THREE (3) possible reactions of carbonyl reduction to form compound F.arrow_forward
- Devise a synthesis of each compound from the given starting material(s). Albuterol is a bronchodilator and proparacaine is a local anesthetic.arrow_forwardNabumetone is a pain reliever and anti-inammatory agent sold under the brand name of Relafen.a. Write out a synthesis of nabumetone from ethyl acetoacetate.b. What ketone and alkyl halide are needed to synthesize nabumetone by direct enolate alkylation?arrow_forwardProcyclidine is a drug that has been used to treat the uncontrolled body movements associated with Parkinson’s disease. Draw three different methods to prepare procyclidine using a Grignard reagent.arrow_forward
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