Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 2, Problem 26P
Interpretation Introduction

Interpretation:

The type of amino acid present in the alpha helix present in the proteins that span biological membranes needs to be determined. The reason for an alpha helix to exist in the environment hydrophobic to the interior of the membrane needs to be explained.

Concept introduction:

Amino acids are organic compounds containing amino as well as carboxylic acid groups. These groups are common in all amino acids.The difference in all amino acids is different R groups. The general representation of an amino acid is as follows:

H2NCH(R)COOH

Here, R group is different for different amino acids. This group can be acidic, basic or neutral.

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4 In the alpha helix shown below, all carbonyl groups are pointing amino groups are pointing Upwards; Downwards Downwards; Downwards O Downwards; Upwards Upwards; Upwards ___, and
-100 100 8. This is a helical wheel projection. The following amino acids of your protein were predicted to participate in an alpha helix: DRMVEHACKSI. a. Plot these amino acids in the helical wheel projection below. b. Is the alpha helix in your protein hydrophobic, amphipathic or hydrophobic? c. Would you expect this helix to be on the interior of the protein, exposed, or partially exposed?
Hydropathy & Amphipathicity 2 -1 -2- 110 210 310 410 510 Residue Number C. Draw the topology of this membrane protein in the bilayer and indicate the range of residues forming transmembrane a-helices.
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