Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Question
Chapter 2, Problem 26P
Interpretation Introduction
Interpretation:
The type of amino acid present in the alpha helix present in the proteins that span biological membranes needs to be determined. The reason for an alpha helix to exist in the environment hydrophobic to the interior of the membrane needs to be explained.
Concept introduction:
Amino acids are organic compounds containing amino as well as
Here, R group is different for different amino acids. This group can be acidic, basic or neutral.
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4
In the alpha helix shown below, all carbonyl groups are pointing
amino groups are pointing
Upwards; Downwards
Downwards; Downwards
O Downwards; Upwards
Upwards; Upwards
___, and
-100
100
8. This is a helical wheel projection. The following amino acids of your protein were predicted to
participate in an alpha helix:
DRMVEHACKSI.
a. Plot these amino acids in the helical
wheel projection below.
b. Is the alpha helix in your protein
hydrophobic, amphipathic or
hydrophobic?
c. Would you expect this helix to be on
the interior of the protein, exposed,
or partially exposed?
Hydropathy & Amphipathicity
2
-1
-2-
110
210
310
410
510
Residue Number
C. Draw the topology of this membrane protein in the bilayer and indicate the range of residues
forming transmembrane a-helices.
Chapter 2 Solutions
Biochemistry
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 5PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10P
Ch. 2 - Prob. 11PCh. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 16PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 29PCh. 2 - Prob. 30PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37P
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- Part I. Protein structure You have the toy model for a protein in the water (W) environment of the cell shown. a) How many residues (amino acids) does this toy protein have? b) How many hydrophobic (H), hydrophilic (P), and charged (C) residues are there? c) Sketch the molecule on your answer sheet and then show the positions of the favorable C-C (charge-charge) interactions on the figure.arrow_forwardOligopeptide 1 Oligopeptide 2 Give the three-letter and one-letter names of the amino acids in each oligopeptide starting from the amino terminal to the carboxyl terminal. Make sure that the amino acid names are arranged in CORRECT order for both oligopeptides. a.arrow_forwardTERTIARY STRUCTURE (A) (B) (C) Fg Eet Galand Sen 20e Figure 6. Examples of the arrangement of a-helices and B-sheets in folded protein domains. Copyright 2013 from Essential Cell Biology, 4th Edition by Alberts et al. Reproduced by permission of Garland Science/ Taylor & Francis LLC. Figure 6 shows three examples of how secondary structure elements can be arranged in relation to one another in the functional, folded form of a complete protein or one compact portion of a protein. The overall three-dimensional shape (or conformation) of a protein is its tertiary structure. • What do you think holds together the various secondary structural elements in a particular three-dimensional pattern? (Hint: Look back at Figure 5 - what is sticking out from the sides of the a-helices and B-strands?)arrow_forward
- Cholesterol is an integral part of plasma membranes. Based on its structure, where is it found in the membrane? on the extracellular surface embedded with the phospholipid heads within the tail bilayer attached to the intracellular surfacearrow_forwardMad cow disease is an infectious disease where one misfolded protein causes all other copies of the protein to being misfolding. This is an example of a disease impacting structure. primary secondary tertiary quaternaryarrow_forwardWhich of the following is a functional group that is part of a building block of proteins? phosphate adenine amino ribosearrow_forward
- The helix and the pleated sheet are part of which protein structure? primary secondary tertiary quaternaryarrow_forwardAmino acids have the generic structure seen below, where R represents different carbon-based side chains. Describe how the structure of amino acids allows them to be linked into long peptide chains to form proteins.arrow_forward2. Subunit Composition of a Protein. A protein has a molecular mass of 400 kDa when measured by size-exclusion chromatography ( F). When subjected to gel electrophoresis in the presence of sodium dodecyl sulfate (SDS), the protein gives three bands with molecular masses of 180, 160, and 60 kDa. When electrophoresis is carried out in the presence of SDS and dithiothreitol (=), three bands are again formed, this time with molecular masses of 160, 90, and 60 kDa. Determine the subunit composition of the protein. Note: dithiothreitol is a reagent to beak down the disulfide bonds.arrow_forward
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