The given link and study the Fragile X syndrome Introduction: Fragile X syndrome- It is an X- linked dominant inherited disease. The condition is characterized by trouble in learning, developmental problems, and intellectual debility. In X- linked dominant diseases, one copy of mutated allele is enough to cause the disease that is present on the X chromosome. The trinucleotide repeats: The DNA- Deoxyribonucleic acid is a double helix structure, comprises three lettered code known as “Codons” or “Trinucleotide repeats”. The disorders that are related to Trinucleotide repeat shows the mutation that exceeds the normal codon repeats per gene or introns, halting the normal functioning of that gene. In Fragile X syndrome, both genders are equally affected, but the severity can be seen more in males than females. The gene that causes Fragile X syndrome is FMR 1 , located on the X chromosome. Females are less likely to be affected as there is (XX) two X chromosome, if one is mutated other can functions normally, while in case of males, there is single X chromosome that makes them prone to be affected. Females tend to show milder effects.

Question

Want to see the full answer?

Answer 1

Question

Chapter 2, Problem 50P

Summary Introduction

To analyze:

The given link and study the Fragile X syndrome

Introduction:

Fragile X syndrome-

It is an X- linked dominant inherited disease. The condition is characterized by trouble in learning, developmental problems, and intellectual debility. In X- linked dominant diseases, one copy of mutated allele is enough to cause the disease that is present on the X chromosome.

The trinucleotide repeats:

The DNA- Deoxyribonucleic acid is a double helix structure, comprises three lettered code known as “Codons” or “Trinucleotide repeats”. The disorders that are related to Trinucleotide repeat shows the mutation that exceeds the normal codon repeats per gene or introns, halting the normal functioning of that gene.

In Fragile X syndrome, both genders are equally affected, but the severity can be seen more in males than females. The gene that causes Fragile X syndrome is FMR 1, located on the X chromosome. Females are less likely to be affected as there is (XX) two X chromosome, if one is mutated other can functions normally, while in case of males, there is single X chromosome that makes them prone to be affected. Females tend to show milder effects.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

Write a short essay that explains how recombinant DNA techniques were used to identify and study genes compared to how modern genomic techniques have revolutionized the cloning and analysis of genes.

Please find an Image/Graphic to represent sickle cell disease: Use at least two different images to help the audience understand the cause and/or inheritance pattern of the disorder you chose. Include a brief 1-2 sentence caption below each image that gives a description of the image and explains its relevance to your chosen disorder. The two images should NOT convey the same exact information. Ideas of images to use include: karyotypes, pedigrees, DNA sequences, etc. Please note: the images should be specific to your chosen disorder. The 2 required images must be related to cause and/or inheritance pattern. Images of an individual with the disorder will not count toward your 2 required images as they do not contribute to the audience's understanding of cause and/or inheritance pattern.

Make up a sentence including the words chromosome,genes, and genome