EBK GENETICS: FROM GENES TO GENOMES
5th Edition
ISBN: 8220100255250
Author: HARTWELL
Publisher: YUZU
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Chapter 21, Problem 8P
Human geneticists have found the Finnish population to be very useful for studies of a variety of conditions. The population is small; Finns have extensive church records documenting lineages; and few people have migrated into Finland. The frequency of some recessive disorders is higher in the Finnish population than elsewhere in the world, and diseases such as PKU and cystic fibrosis that are common elsewhere do not occur in the Finnish population.
| a. | How would a population geneticist explain these variations in disease occurrence? |
| b. | The Finnish population is also a source of information for the study of quantitative traits. The genetic basis of schizophrenia is one question that can be explored in this population. What advantage(s) and disadvantage(s) can you imagine for studying complex traits based on the Finnish population structure? |
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Students have asked these similar questions
Discuss the role of mutation in the origin of genetic polymorphisms. Suppose that a genetic polymorphism involves two alleles at frequencies of 0.45 and 0.55. Describe three different scenarios to explain these observed allele frequencies. You can propose that the mutations that produced the polymorphism are neutral, beneficial, or deleterious.
Please help with the following:
How does penetrance differ from expressivity in genetics?
A. Penetrance is the percentage of individuals with a specific genotype that exhibit the expected phenotype while expressivity is the degree to which a phenotypic character is expressed.
B. Penetrance is the degree of lethality of a specific genotype while expressivity is how frequently that genotype is seen in the population.
C. Penetrance is the presence of more than two alleles at a locus within a group of individuals while expressivity is the influence of sex on which alleles express themselves.
D. None of the above.
E. Penetrance refers to the paternal effects of a gene while expressivity refers to the maternal effects of a gene.
.. Nowadays, newborn babies are required to be tested for
phynylketonuria (PKU), an autosomal recessive genetic disorder. If
untreated, individual homozygous for PKU suffer mental retardation. In a
recent year, 4 PKU babies were detected out of 126,000 tested. Assuming
Hardy-Weinberg conditions, what is the frequency of the PKU gene in this
population (Give your answer in decimal number with 3 decimal places)?
Chapter 21 Solutions
EBK GENETICS: FROM GENES TO GENOMES
Ch. 21 - Choose the best matching phrase in the right...Ch. 21 - Prob. 2PCh. 21 - How can each of the following be used in...Ch. 21 - Which of the following statements would be true of...Ch. 21 - Prob. 5PCh. 21 - Prob. 6PCh. 21 - Prob. 7PCh. 21 - Human geneticists have found the Finnish...Ch. 21 - Prob. 9PCh. 21 - Prob. 10P
Ch. 21 - In a certain plant, leaf size is determined by...Ch. 21 - Compare and contrast the use of SNP genotyping: i...Ch. 21 - Prob. 13PCh. 21 - Prob. 14PCh. 21 - Canavan disease, caused by homozygosity for a...Ch. 21 - Prob. 16PCh. 21 - Prob. 17PCh. 21 - Consider the triangle diagram shown in Fig. 21.15....Ch. 21 - Prob. 19PCh. 21 - Prob. 20PCh. 21 - Suppose a GWAS investigation found a particular LD...Ch. 21 - In domesticated dogs, size has a high...Ch. 21 - Prob. 23P
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