HUMAN BIOLOGY
16th Edition
ISBN: 9781260233032
Author: Mader
Publisher: RENT MCG
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Chapter 21.4, Problem 2BTS
Summary Introduction
To determine:
The difficulty in using genetic engineering to modify a trait that is determined by multiple gene interactions.
Introduction:
Genetic engineering is a technique of modifying an organism genetically. Modification in the genotype is generated using procedures of
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Chapter 21 Solutions
HUMAN BIOLOGY
Ch. 21.1 - Distinguish between a genotype and a phenotype.Ch. 21.1 - Define allele, gene, dominant, and recessive as...Ch. 21.1 - Prob. 3LOCh. 21.1 - Define the following terms:Â gene, allele, locus,...Ch. 21.1 - Prob. 2CYPCh. 21.1 - Prob. 3CYPCh. 21.2 - Prob. 1LOCh. 21.2 - Calculate the probability of a specific genotype...Ch. 21.2 - Prob. 1CYPCh. 21.2 - Prob. 2CYP
Ch. 21.2 - Using a dihybrid cross as an example (see Fig....Ch. 21.3 - Interpret a human pedigree to identify the pattern...Ch. 21.3 - Prob. 2LOCh. 21.3 - Solve the following: In a pedigree, all the...Ch. 21.3 - Prob. 2CYPCh. 21.3 - Explain why some incidences of autosomal recessive...Ch. 21.4 - Prob. 1LOCh. 21.4 - Prob. 2LOCh. 21.4 - Prob. 3LOCh. 21.4 - Prob. 1BTSCh. 21.4 - Prob. 2BTSCh. 21.4 - Prob. 1CYPCh. 21.4 - Prob. 2CYPCh. 21.4 - Discuss the potential evolutionary advantages of...Ch. 21.5 - Prob. 1LOCh. 21.5 - Prob. 2LOCh. 21.5 - Prob. 1CYPCh. 21.5 - Prob. 2CYPCh. 21.5 - Discuss why X-linked disorders are more common...Ch. 21.5 - Prob. 1BTSCh. 21.5 - Prob. 2BTSCh. 21 - Prob. 1ACh. 21 - 2. Which of the toll awing terms refers to...Ch. 21 - Prob. 3ACh. 21 - Prob. 4ACh. 21 - 5. The genotype of an individual with the dominant...Ch. 21 - Prob. 6ACh. 21 - Prob. 7ACh. 21 - Prob. 8ACh. 21 - Which of the following disorders is caused by a...Ch. 21 - Prob. 10ACh. 21 - Prob. 11ACh. 21 - Prob. 12ACh. 21 - Which of the following terms may be used to...Ch. 21 - Prob. 14ACh. 21 - Prob. 15ACh. 21 - Prob. 1TCCh. 21 - Prob. 2TCCh. 21 - Prob. 3TC
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- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forward
- Will insurance companies be able to deny coverage or even treatment of illnesses that can now be revealed through in utero genetic testing?arrow_forwardCould you please help find the type of trait and genetic interactions shown in this picture?arrow_forwardWhat is pedigree Analysis? What are its use or uses?arrow_forward
- Suppose that you are at a party on Friday night, relaxing after your big genetics exam. Someone comes up to you and, hearing that you just finished your genetics exam, says, “What exactly is a gene?” How would you respond? What are the strengths and weaknesses of your definition of a gene?arrow_forwardHow do geneticists detect the presence of genetic variation as different alleles in a population?arrow_forwardWhat are the causes of pedigree analysis?arrow_forward
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