BUNDLE:3 ITEM PACKAGE
8th Edition
ISBN: 9780134865201
Author: Bruice
Publisher: PEARSON
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Textbook Question
Chapter 22, Problem 40P
At pH = 12, the rate of hydrolysis of ester A is greater than the rate of hydrolysis of ester B. At pH = 8, the relative rates reverse (that is, ester B hydrolyzes faster than ester A). Explain these observations.
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1. Put these three common types of carbonyl compound in order of decreasing reactivity
ester amide acid chloride
2. For the least reactive, show the interconversion to its other resonance form: How does this electron delocalisation make it stable?
3. For the most reactive, draw the mechanism of its undergoing hydrolysis (reaction with H2O):
Why makes this type of carbonyl so reactive to nucleophiles?
Order the following in increasing acid strength and explain your reasoning.
a. Benzoic Acid, b. 4-nitrobenzoic acid, c. 4-methylbenzoic acid, d. 4-methoxybenzoic acid
Maleic Acid + Bromine à racemic-2,3-Dibromosuccinic Acid
Explain the mechanism and reaction
Chapter 22 Solutions
BUNDLE:3 ITEM PACKAGE
Ch. 22.2 - Compare each of the mechanisms listed here with...Ch. 22.2 - Prob. 3PCh. 22.2 - Prob. 4PCh. 22.3 - a. Draw the mechanism for the following reaction...Ch. 22.5 - Prob. 7PCh. 22.5 - Propose a mechanism for the Co2+ catalyzed...Ch. 22.6 - Prob. 9PCh. 22.7 - Prob. 10PCh. 22.7 - Prob. 12PCh. 22.7 - Prob. 13P
Ch. 22.9 - Which of the following amino acid side chains can...Ch. 22.9 - Which of the following C-terminal peptide bonds is...Ch. 22.9 - Carboxypeptidase A has esterase activity as well...Ch. 22.10 - Arginine and lysine side chains fit into trypsins...Ch. 22.10 - Explain why serine proteases do not catalyze...Ch. 22.11 - If H2 18O is used in the hydrolysis reaction...Ch. 22.11 - Draw the pH-activity profile for an enzyme that...Ch. 22.12 - The pHactivity profile for glucose-6-phosphate...Ch. 22.12 - Prob. 23PCh. 22.13 - Draw the mechanism for the hydroxide ion-catalyzed...Ch. 22.13 - What advantage does the enzyme gain by forming an...Ch. 22.13 - Prob. 26PCh. 22.13 - Prob. 27PCh. 22.13 - Aldolase shows no activity if it is incubated with...Ch. 22 - Which of the following parameters would be...Ch. 22 - Prob. 29PCh. 22 - Prob. 30PCh. 22 - Prob. 31PCh. 22 - Indicate the type of catalysis that is occurring...Ch. 22 - The deuterium kinetic isotope effect (KH2O/KD2O)...Ch. 22 - Prob. 34PCh. 22 - Co2+ catalyzes the hydrolysis of the lactam shown...Ch. 22 - there are two kinds of aldolases. Class I...Ch. 22 - Prob. 37PCh. 22 - The hydrolysis of the ester shown here is...Ch. 22 - Prob. 39PCh. 22 - At pH = 12, the rate of hydrolysis of ester A is...Ch. 22 - 2-Acetoxycyclohexyl tosylate reacts with acetate...Ch. 22 - Proof that an imine was formed between aldolase...Ch. 22 - Prob. 43PCh. 22 - a. Explain why the alkyl halide shown here reacts...Ch. 22 - Triosephosphate isomerase (TIM) catalyzes the...
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