Organic Chemistry (Package) (Looseleaf)
7th Edition
ISBN: 9780321939036
Author: Bruice
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Textbook Question
Chapter 23, Problem 34P
The deuterium kinetic isotope effect (KH2O/KD2O) for the hydrolysis of aspirin is 2.2. What does this tell you about the kind of catalysis exerted by the ortho-carboxyl substituent? (Hint: It is easier to break an O — H bond than an O — D bond.)
Expert Solution & Answer
Trending nowThis is a popular solution!
Students have asked these similar questions
The deuterium kinetic isotope effect (kH2O/kD2O) for the hydrolysis of aspirin is 2.2. What does this tell you about the kind of catalysis exerted by the ortho-carboxyl substituent? (Hint: It is easier to break an O¬H bond than an O¬D bond.)
To synthesize Tylenol, p-aminophenol will be acetylated using 1.4 equivalents of acetic anhydride. Starting with 2.1 g p-aminophenol, how what volume (in mL) of acetic anhydride is required?
a. Give at least three characteristics of dichloromethane that makes it a good extracting solvent for the alkaloid.b. Why is it necessary to remove a stopper from a separatory funnel when the liquid is being drained from it through a stopcock?c. What are emulsions? Why do they form during extractions? How is the formation of an emulsion minimized? How are emulsions removed?
Chapter 23 Solutions
Organic Chemistry (Package) (Looseleaf)
Ch. 23.2 - Compare each of the mechanisms listed here with...Ch. 23.2 - Prob. 3PCh. 23.2 - Prob. 4PCh. 23.3 - a. Draw the mechanism for the following reaction...Ch. 23.5 - Prob. 7PCh. 23.5 - Propose a mechanism for the Co2+ catalyzed...Ch. 23.6 - Prob. 9PCh. 23.7 - Prob. 10PCh. 23.7 - Prob. 12PCh. 23.7 - Prob. 13P
Ch. 23.9 - Which of the following amino acid side chains can...Ch. 23.9 - Which of the following C-terminal peptide bonds is...Ch. 23.9 - Carboxypeptidase A has esterase activity as well...Ch. 23.9 - Arginine and lysine side chains fit into trypsins...Ch. 23.9 - Explain why serine proteases do not catalyze...Ch. 23.10 - If H2 18O is used in the hydrolysis reaction...Ch. 23.10 - When apples that have been cut are exposed to...Ch. 23.11 - Prob. 22PCh. 23.11 - The pHactivity profile for glucose-6-phosphate...Ch. 23.11 - Draw the pH-activity profile for an enzyme that...Ch. 23.12 - Prob. 25PCh. 23.12 - Draw the mechanism for the hydroxide ion-catalyzed...Ch. 23.12 - What advantage does the enzyme gain by forming an...Ch. 23.12 - Prob. 28PCh. 23.12 - Aldolase shows no activity if it is incubated with...Ch. 23 - Which of the following parameters would be...Ch. 23 - Prob. 30PCh. 23 - Prob. 31PCh. 23 - Prob. 32PCh. 23 - Indicate the type of catalysis that is occurring...Ch. 23 - The deuterium kinetic isotope effect (KH2O/KD2O)...Ch. 23 - Prob. 35PCh. 23 - Co2+ catalyzes the hydrolysis of the lactam shown...Ch. 23 - there are two kinds of aldolases. Class I...Ch. 23 - Prob. 38PCh. 23 - The hydrolysis of the ester shown here is...Ch. 23 - Prob. 40PCh. 23 - At pH = 12, the rate of hydrolysis of ester A is...Ch. 23 - 2-Acetoxycyclohexyl tosylate reacts with acetate...Ch. 23 - Proof that an imine was formed between aldolase...Ch. 23 - Prob. 44PCh. 23 - a. Explain why the alkyl halide shown here reacts...Ch. 23 - Triosephosphate isomerase (TIM) catalyzes the...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Similar questions
- Give the functions of the following ingredients, then name a branded/commercial skin or hair care product where the said material is used. Tetrasodium EDTA Cholesterol Silicone Oil 200/50 cst BETAINE Carbopol Ultrez D & C Red No. 17 ( CI No. 26100) Bisabolol (Alpha Bisabolol) Ceresin Wax Disodium Lauryl Sulfosuccinate Hydroxypropyl Methylcellulosearrow_forwardA student was trying to determine the identity of an unknown compound. The melting point of the compound was 117-118oC. The student narrowed the possible compound down to the following: Compound Melting Point Range acetanilide 113-115oC fluorene 114-116oC mandelic acid 120-122oC A second student, doing the same experiment as above, found that their melting point was 100-108oC. What is wrong with the student’s melting point? Propose two reasons why the melting point could be incorrect. View keyboard shortcutsarrow_forward1. After 3 hours, Ibuprofen is at 100mg 2. m(t)=400e^−0.462t, K=0.462 Please answer question 5.arrow_forward
- Give at least three characteristics of chloroform that make it a good extracting solvent for the alkaloid.arrow_forwardQ1. Discuss the role of the following reagents in the extraction of caffeine. a. Vinegarb. Baking soda Q2. What are emulsions? Why do they form during extractions? How is their formation minimized? Q3. Why is it necessary to turn the separatory funnel upside down and to open thestopcock?arrow_forwardWhich of these amines would produce the salt with the highest melting point if mixed separately with hydrochloric acid (HCl)? Based on the structure and properties of the resulting ammonium salts, explain your reasoningarrow_forward
- A student was trying to determine the identity of an unknown compound. The melting point of the compound was 117-118oC. The student narrowed the possible compound down to the following: Compound Melting Point Range acetanilide 113-115oC fluorene 114-116oC mandelic acid 120-122oC Explain in detail how the student can experimentally determine and confirm the identity of their unknown.arrow_forwardDoes it safe to use this sunscreen K on acne prone skin. And can we rinse off it by only using facial gel mixed with water to rinse off it without use oil. Do I need to use micellar water for removing cosmetic before rinse off it with facial gel Sunscreen K has lists of ingredients below (descending order)…. AQUA DIMETHICONE CYCLOPENTASILOXANE PROPYLENE GLYCOL NIACINAMIDE DIETHYLHEXYL CARBONATE ZINC OXIDE CETEARYL ALCOHOL POLYMETHYL METHACRYLATE SODIUM POLYACRYLOYL-DIMETHYL TAURATE TITANIUM DIOXIDE ETHYLHEXYL METHOXYCINNAMATE BUTYL METHOXYDIBENZOYLMETHANE GLYCERYL STEARATE BIS-PEG/PPG-20/5 PEG/PPG-20/5 DIMETHICONE METHOXY PEG/PPG-25/4 DIMETHICONE HYDROGENATED POLYDECENE BUTYLENE GLYCOL OCTOCRYLENE PEG-40 STEARATE PHENOXYETHANOL HEXYL LAURATE POLYHYDROXYSTEARIC ACID CAPRYLIC/CAPRIC TRIGLYCERIDE STEARIC ACID CETYL ALCOHOL PEG-10 DIMETHICONE CETEARETH-20 TOCOPHERYL ACETATE STEARYL ALCOHOl PHENYL TRIMETHICONE TRIETHOXYCAPRYLYSILANE TRIDECETH-10 CHLORPHENESIN DISODIUM EDTA DIMETHICONOL…arrow_forwardIllustrate all the locations where 2-methylocta-4,6-dien-1-amine could form hydrogen bonds with water either as a hydrogen donor or as a target (receiver) of hydrogen bonds from water. Do this by drawing bent water molecules as necessary and representing hydrogen bonds between water and the molecule using dashed lines. Be sure it is clear exactly which atoms on each molecule are involved in the hydrogen bonds. If it is not capable of forming hydrogen bonds with water explain why not.arrow_forward
- Explain this difference in potency and speed of onset by pointing out the main differences in functional groups between morphine and heroin.arrow_forwardGiven that your mixture containing benzoic acid and aminobenzene dissolved in n-hexane solvent. Suggest a method on how to separate these two substances. Available reagents: A. Hydrochloric acid B. Sodium hydroxide C. Distilled water D. n-hexanearrow_forwardA bloodhound, with an acute sense of smell, sits at one end of a long, unventilated corridor.At the other end of the corridor a small amount of an aerosol is released containing the volatile, fragrant compounds: acetaldehyde (C2H4O) jasmine lactone (C10H16O2) acetoin (C4H8O2) hexyl acetate (C8H16O2) 1-octen-3-one (C8H14O) Rank the compounds in the chronological order they are detected by the hound. 1-octen-3-one acetoin jasmine lactone hexyl acetate acetaldehydearrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning
Organic Chemistry
Chemistry
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:Cengage Learning
Enzymes - Effect of cofactors on enzyme; Author: Tutorials Point (India) Ltd;https://www.youtube.com/watch?v=AkAbIwxyUs4;License: Standard YouTube License, CC-BY
Enzyme Catalysis Part-I; Author: NPTEL-NOC IITM;https://www.youtube.com/watch?v=aZE740JWZuQ;License: Standard Youtube License