The possible reactants that would be placed in boxes in the sequence of Sonogashira coupling has to be given. Concept Introduction: Sonogashira coupling starts with a terminal alkyne with C u I and triethylamine to create a Cu- alkyne complex. This undergoes reaction with vinyl or aryl iodides. This coupling is used to create diaryl alkynes , aryl alkenyl alkynes, or dialkenyl alkynes.

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Chapter 24, Problem 24.31P

Interpretation Introduction

Interpretation:

The possible reactants that would be placed in boxes in the sequence of Sonogashira coupling has to be given.

Concept Introduction:

Sonogashira coupling starts with a terminal alkyne with CuI and triethylamine to create a Cu- alkyne complex. This undergoes reaction with vinyl or aryl iodides.

This coupling is used to create diaryl alkynes, aryl alkenyl alkynes, or dialkenyl alkynes.

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[Review Topics] [References] Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction. H3C CH3 H2O NaOH • You do not have to consider stereochemistry. • Include all valence lone pairs in your answer. • Do not include counter-ions, e.g., Nat, I', in your answer. • In cases where there is more than one answer, just draw one. C opy aste C. Previous Next Email Instructor Save and Ex Cengage Learning | Cengage Technical Support 5:48 PI 82°F 3/28/20