(a)
Interpretation:
The compounds needed to carry out Step [1] are to be stated.
Concept introduction:
In crossed claisen condensation reaction, the base abstracts the acidic proton from
(b)
Interpretation:
The compounds needed to carry out Step [1] are to be stated.
Concept introduction:
In crossed claisen condensation reaction, the base abstracts the acidic proton from
(c)
Interpretation:
The detailed mechanism for step [3] is to be drawn.
Concept introduction:
When only one carbonyl component has an alpha hydrogen atom, then a cross aldol reaction will occur. There will be formation of only one product. The yield of single cross aldol condensation reaction is enhanced if the electrophilic carbonyl compound is relatively unhindered.
(d)
Interpretation:
The detailed mechanism for step [4] is to be drawn. The reason as to why the product formed is unusual is to be stated.
Concept introduction:
When only one carbonyl component has an alpha hydrogen atom, then a cross aldol reaction will occur. There will be formation of only one product. The yield of single cross aldol condensation reaction is enhanced if the electrophilic carbonyl compound is relatively unhindered.
(e)
Interpretation:
The reason behind the unnecessary addition and removal of formyl group is to be predicted.
Concept introduction:
When only one carbonyl component has an alpha hydrogen atom, then a cross aldol reaction will occur. There will be formation of only one product. The yield of single cross aldol condensation reaction is enhanced if the electrophilic carbonyl compound is relatively unhindered.
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Organic Chemistry - With Access (Custom)
- In the box to the left of each reaction below, write the mechanism by which it occurs (could be SN1, SN2, or E1, or even 2 of them). Then draw the product(s).arrow_forwardWhich is the better retrosynthesis for the given target molecule? Explain, and provide a one-step synthesis of the target molecule. A A is the better starting material because B can form both E and Z alkenes. B A is the better starting material because it will produce only the desired target molecule. C B is the better starting material because only B has β protons in the trans position. D B is the better starting material because A can form both E and Z alkenes. E B is the better starting material because it will produce only the desired target molecule. F A is the better starting material because only A has β protons in the trans position.arrow_forwardWhy we need step 3 before step 4? a. Because the nitro group increases the electrophilicity at the ortho positions which is where the bromine is added. b. Because the amine group is a strong ortho, para director which is what controls the regiochemical outcome of this bromination. c. Step 4 is unessesary. The symmetry of compound 3 allows for the bromination to be regioselective and give compound 5. 5. There will be a mixture of products because there is no selectivity for a major product.arrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning