a) Interpretation: The major product expected when the amine shown undergoes Hofmann elimination is to be given. Concept introduction: Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Question

What product(s) would you expect from the Hofmann elimination of the following amines? If more than one products are formed, identify, with reasons the major product.

Answer 1

Question

Chapter 24.SE, Problem 62AP

Interpretation Introduction

a)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Interpretation Introduction

b)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Interpretation Introduction

c)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

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Answer 2

Question

Chapter 24.SE, Problem 62AP

Interpretation Introduction

a)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Interpretation Introduction

b)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Interpretation Introduction

c)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

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Answer 3

Question

Chapter 24.SE, Problem 62AP

Interpretation Introduction

a)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Interpretation Introduction

b)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Interpretation Introduction

c)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

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Answer 4

Question

Chapter 24.SE, Problem 62AP

Interpretation Introduction

a)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Interpretation Introduction

b)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Interpretation Introduction

c)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

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Answer 5

Chapter 24.SE, Problem 62AP

Interpretation Introduction

a)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Interpretation Introduction

b)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Interpretation Introduction

c)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Answer 6

Chapter 24.SE, Problem 62AP

Interpretation Introduction

a)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Answer 7

Chapter 24.SE, Problem 62AP

Interpretation Introduction

a)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Answer 8

Interpretation Introduction

b)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Answer 9

Interpretation Introduction

b)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Answer 10

Interpretation Introduction

c)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Answer 11

Interpretation Introduction

c)

Interpretation:

The major product expected when the amine shown undergoes Hofmann elimination is to be given.

Concept introduction:

Hofmannâ€™s rule is applicable to elimination reactions involving positively charged and bulky leaving groups. According to this rule, when two possibilities exist in an elimination reaction, the hydrogen is eliminated from the carbon with more number of hydrogen atoms so that a less substituted alkene will be the major product.

Answer 12

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Answer 23

Ch. 24.1 - Name the following compounds:Ch. 24.1 - Prob. 2P Ch. 24.1 - Prob. 3P Ch. 24.3 - Prob. 4P Ch. 24.3 - The benzylammonium ion (C6H5CH2NH3+) has pKa =...Ch. 24.4 - Prob. 6P Ch. 24.5 - Prob. 7P Ch. 24.6 - Prob. 8P Ch. 24.6 - Prob. 9P Ch. 24.6 - Show two methods for the synthesis of dopamine, a...

Solution Summary: The author describes the major product expected when the amine shown undergoes Hofmann elimination.

Chapter 24 Solutions