Chapter 25, Problem 25.13UKC

Interpretation Introduction

Interpretation:

The two enzymes that is necessary to detoxify the ammonium ion in the presence of pyruvate and the product formed has to be identified.

Concept introduction:

• Transamination of amino acid is the reaction in which amino group is converted to keto acid and formation of a new amino acid takes place.
• The reaction is the interchange of amino group from given amino acid with the keto group from $\text{α-ketoglutarate}$. During transamination reaction $\text{α-ketoglutarate}$ gives glutamate as the product. The product from the amino acid is the keto group.
• Oxidative deamination is the removal of $-N{H}_4{}^{+}$ bonded to $\alpha -carbon$ and replacing them by a $C=O$ gives the desired $\text{α-keto}\text{acid}$.
• Hyperammonemia is a disease caused as a result of excess of $-N{H}_4{}^{+}$ in the blood.