Concept explainers
(a)
Interpretation: The carbonyl and nitrogen compounds needed to prepare the given compound using reductive amination are to be determined.
Concept introduction: The conversion of
(b)
Interpretation: The carbonyl and nitrogen compounds needed to prepare the given compound using reductive amination are to be determined.
Concept introduction: The conversion of aldehydes and ketones into amines is known as reductive amination. The first step is the formation of imines using aldehydes or ketones and amines. The second step involves the reduction of imine to form amine. The best reagent for this reaction is sodiumcyanoborohydride.
(c)
Interpretation: The carbonyl and nitrogen compounds needed to prepare the given compound using reductive amination are to be determined.
Concept introduction: The conversion of aldehydes and ketones into amines is known as reductive amination. The first step is the formation of imines using aldehydes or ketones and amines. The second step involves the reduction of imine to form amine. The best reagent for this reaction is sodiumcyanoborohydride.
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ORGANIC CHEMISTRY W/BIO...-STUD.SOLN.
- What product is formed when A is treated with Grubbs catalyst underhigh-dilution conditions? This reaction was a key step in the synthesis ofstemoamide, the naturally occurring amide described in the opening paragraph.arrow_forwardSafrole, which is isolated from sassafras (Problem 21.33), can be converted to the illegal stimulant MDMA (3,4- methylenedioxymethamphetamine, “Ecstasy”) by a variety of methods. (a) Devise a synthesis that begins with safrole and uses a nucleophilic substitution reaction to introduce the amine. (b) Devise a synthesis that begins with safrole and uses reductive amination to introduce the amine.arrow_forwardTyramine is an alkaloid found in mistletoe and ripe cheese. Dopamine is a neurotransmitter involved in the regulation of the central nervous system. a. How can tyramine be prepared from β-phenylethylamine?b. How can dopamine be prepared from tyramine?c. Give two ways to prepare β-phenylethylamine from β-phenylethyl chloride.d. How can β-phenylethylamine be prepared from benzyl chloride?e. How can β-phenylethylamine be prepared from benzaldehyde?arrow_forward
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- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning