(a)
Interpretation: The synthesis of given compound from aniline as starting material is to be devised.
Concept introduction: The formation of diazonium salt from
(b)
Interpretation: The synthesis of given compound from aniline as starting material is to be devised.
Concept introduction: The formation of diazonium salt from aromatic amines takes place using sodium nitrite and hydrochloric acid at low temperatures. This process is known as diazotization. The diazonium salts can be converted to aryl halides using cuprous halides or aryl cyanides using cuprous cyanides.
Friedel-Crafts alkylation permits the synthesis of alkylated products by the reaction of arenes with alkyl chlorides in the presence of aluminium chloride (Lewis acid). This alkylation reaction comes under the category of electrophilic aromatic substitution.
(c)
Interpretation: The synthesis of given compound from aniline as starting material is to be devised.
Concept introduction: The formation of diazonium salt from aromatic amines takes place using sodium nitrite and hydrochloric acid at low temperatures. This process is known as diazotization. The diazonium salts can be converted to aryl halides using cuprous halides or aryl cyanides using cuprous cyanides.
Diazonium salts form azo compounds with aromatic phenols or aromatic amines.
Friedel-Crafts alkylation permits the synthesis of alkylated products by the reaction of arenes with alkyl chlorides in the presence of aluminium chloride (Lewis acid). This alkylation reaction comes under the category of electrophilic aromatic substitution.
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Chapter 25 Solutions
ORGANIC CHEMISTRY LSLF W/CONNECT >BI<
- Devise a synthesis of each compound from the indicated starting material:arrow_forwardDevise a synthesis of muscalure, the sex pheromone of the common housey, from acetylene and any other required reagents.arrow_forwardDevise a synthesis of each compound from the given starting material(s). Albuterol is a bronchodilator and proparacaine is a local anesthetic.arrow_forward
- Devise a synthesis of muscalure, the sex pheromone of the common housefly, from acetylene and any other required reagents.arrow_forwardDraw a stepwise mechanism for the following reactions, two steps in R. B. Woodward’s classic synthesis of reserpine in 1958. Reserpine, which is isolated from the extracts of the Indian snakeroot Rauwola serpentina Benth, was used at one time to manage mild hypertension associated with anxiety.arrow_forwardCarboxylic acid X is an intermediate in the multistep synthesis of proparacaine, a local anesthetic. Devise a synthesis of X from phenol and any needed organic or inorganic reagents.arrow_forward
- Draw a stepwise mechanism for the following reactions, two steps in R. B. Woodward’s classic synthesis of reserpine in 1958. Reserpine, which is isolated from the extracts of the Indian snakeroot Rauwolfia serpentina Benth, was used at one time to manage mild hypertension associated with anxiety.arrow_forwardCarboxylic acid X is an intermediate in the multistep synthesis ofproparacaine, a local anesthetic. Devise a synthesis of X from phenoland any needed organic or inorganic reagents.arrow_forwardDraw a stepwise mechanism for the attached reaction, which involves two Friedel–Crafts reactions. B was an intermediate in the synthesis of the antidepressant sertralinearrow_forward
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