Organic Chemistry, Binder Ready Version
Organic Chemistry, Binder Ready Version
2nd Edition
ISBN: 9781118454312
Author: David R. Klein
Publisher: WILEY
Question
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Chapter 25, Problem 58PP
Interpretation Introduction

Interpretation:

Why alkyl halide is not required for the synthesis of glycine by amidomalonate synthesis need to be explained.

Concept introduction:

Amidomalonate synthesis is a process in which a halide is converted to a aminoacid with two new carbon atoms (comes from amidomalonate).  By use of this method a new alkyl groups can be introduced.  A general scheme of this synthesis is shown below,

Organic Chemistry, Binder Ready Version, Chapter 25, Problem 58PP

Steps involved in amidomalonater synthesis are,

  • Deprotonation of α carbon in amidomalonate
  • Alkylation of enolate
  • Hydrolysis of ester using aqueous acid
  • Decarboxylation at high temperature

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Chapter 25 Solutions

Organic Chemistry, Binder Ready Version

Ch. 25.2 - Prob. 10CCCh. 25.3 - Prob. 11CCCh. 25.3 - Prob. 12CCCh. 25.3 - Prob. 13CCCh. 25.3 - Prob. 2LTSCh. 25.3 - Prob. 14PTSCh. 25.3 - Prob. 15ATSCh. 25.3 - Prob. 16ATSCh. 25.3 - Prob. 17CCCh. 25.3 - Prob. 18CCCh. 25.3 - Prob. 19CCCh. 25.3 - Prob. 20CCCh. 25.4 - Prob. 3LTSCh. 25.4 - Prob. 21PTSCh. 25.4 - Prob. 22ATSCh. 25.4 - Prob. 23ATSCh. 25.4 - Prob. 24ATSCh. 25.4 - Prob. 25CCCh. 25.4 - Prob. 26CCCh. 25.4 - Prob. 27CCCh. 25.4 - Prob. 28CCCh. 25.4 - Prob. 29CCCh. 25.5 - Prob. 30CCCh. 25.5 - Prob. 4LTSCh. 25.5 - Prob. 31PTSCh. 25.5 - Prob. 32ATSCh. 25.5 - Prob. 33ATSCh. 25.6 - Prob. 5LTSCh. 25.6 - Prob. 34PTSCh. 25.6 - Prob. 35ATSCh. 25.6 - Prob. 36ATSCh. 25.6 - Prob. 6LTSCh. 25.6 - Prob. 37PTSCh. 25.6 - Prob. 38PTSCh. 25.7 - Prob. 39CCCh. 25 - Prob. 40PPCh. 25 - Prob. 41PPCh. 25 - Prob. 42PPCh. 25 - Prob. 43PPCh. 25 - Prob. 44PPCh. 25 - Prob. 45PPCh. 25 - Prob. 46PPCh. 25 - Prob. 47PPCh. 25 - Prob. 48PPCh. 25 - Prob. 49PPCh. 25 - Prob. 50PPCh. 25 - Prob. 51PPCh. 25 - Prob. 52PPCh. 25 - Prob. 53PPCh. 25 - Prob. 54PPCh. 25 - Prob. 55PPCh. 25 - Prob. 56PPCh. 25 - Prob. 57PPCh. 25 - Prob. 58PPCh. 25 - Prob. 59PPCh. 25 - Prob. 60PPCh. 25 - Prob. 61PPCh. 25 - Prob. 62PPCh. 25 - Prob. 63PPCh. 25 - Prob. 64PPCh. 25 - Prob. 65PPCh. 25 - Prob. 66PPCh. 25 - Prob. 67PPCh. 25 - Prob. 68PPCh. 25 - Prob. 69PPCh. 25 - Prob. 70PPCh. 25 - Prob. 71PPCh. 25 - Prob. 72PPCh. 25 - Prob. 73PPCh. 25 - Prob. 74PPCh. 25 - Prob. 75PPCh. 25 - Prob. 76PPCh. 25 - Prob. 77PPCh. 25 - Prob. 78PPCh. 25 - Prob. 79PPCh. 25 - Prob. 80PPCh. 25 - Prob. 81PPCh. 25 - Prob. 82PPCh. 25 - Prob. 83PPCh. 25 - Prob. 84IPCh. 25 - Prob. 85IPCh. 25 - Prob. 86IPCh. 25 - Prob. 87IP
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