5-Bromouracil causes mutations in DNA. Reason for this should be determined. Concept introduction: A parent DNA molecule consists of two poly nucleotide chains held together by bonds between complementary nitrogen bases. A base is nitrogen containing heterocyclic compound which is found in DNA and RNA. There are mainly five nitrogen bases. (1) Adenine (2) Guanine (3) Cytosine (4) Thymine (5) Uracil In DNA Adenine always makes a double bond with Thymine ( A = T ) and cytosine always makes triple bond with guanine ( G ≡ C ) Enol is a tautomer which exhibiting a special type of functional isomerism namely tautomerism. Tautomerism is a special type of functional isomerism in which isomers are in dynamic equilibrium with each other. Mutation is the process that results in change in the sequence of the DNA, and the compound which causes mutation is known as mutagenic compound.

Question

In much the same way that aldoses are reduced with H 2 and Pd, 2-ketohexoses are also reduced. One difference occurs, however, in that two products are formed on reduction of 2-ketohexoses. Draw the two products formed when fructose (Section 20.2C) is reduced, and label the products as stereoisomers, constitutional isomers, or anomers. Explain your choice.

Answer 1

Question

Chapter 26, Problem 36P

Interpretation Introduction

Interpretation:

5-Bromouracil causes mutations in DNA. Reason for this should be determined.

Concept introduction:

A parent DNA molecule consists of two poly nucleotide chains held together by bonds between complementary nitrogen bases.

A base is nitrogen containing heterocyclic compound which is found in DNA and RNA.

There are mainly five nitrogen bases.

(1) Adenine

(2) Guanine

(3) Cytosine

(4) Thymine

(5) Uracil

In DNA Adenine always makes a double bond with Thymine (A=T) and cytosine always makes triple bond with guanine (G≡C)

Enol is a tautomer which exhibiting a special type of functional isomerism namely tautomerism.

Tautomerism is a special type of functional isomerism in which isomers are in dynamic equilibrium with each other.

Mutation is the process that results in change in the sequence of the DNA, and the compound which causes mutation is known as mutagenic compound.

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In much the same way that aldoses are reduced with H 2 and Pd, 2-ketohexoses are also reduced. One difference occurs, however, in that two products are formed on reduction of 2-ketohexoses. Draw the two products formed when fructose (Section 20.2C) is reduced, and label the products as stereoisomers, constitutional isomers, or anomers. Explain your choice.

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