BIOLOGY 12TH ED (LL) W/ CONNECT
BIOLOGY 12TH ED (LL) W/ CONNECT
12th Edition
ISBN: 9781264898091
Author: Raven
Publisher: MCG
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Chapter 26, Problem 4S
Summary Introduction

To explain: The way through which a highly infectious strain of the virus that targets and destroys neurons might be changed so that it could deliver a gene to correct cystic fibrosis in lung tissue.

Introduction: Viruses are intracellular obligate parasites that require a host cell to proliferate. They take over the machinery of the host cell that it infects and reproduces within the host cell. They possess either DNA or RNA genome, which is surrounded by the protein capsid.

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Some older vaccines used a weakened strain of the pathogenic virus in the injection in the hope that the weakened virus would induce an immune response without causing disease. The virus vectors used in genetic engineering have all the harmful virus genes cut out and replaced with the foreign gene, such as one that makes a protein that is absent in the human patient. Which type of viral vaccine would you prefer to take as the safest option? Why? Some Covid 19 vaccines in development use the adenovirus, a common vector used in gene therapies, to inject the mRNa for the spike protein into human muscle cells. Why might vaccines using a virus vector be more likely to need only refrigeration and not deep-cold storage, given what you know about viruses?
Some retroviruses that have a wide host range have been developed for use in treatment of diseases or syndromes. These viruses do not result in a productive infection because they lack critical genes for viral replication, but they do carry DNA sequences that allow them to be packaged into infectious particles. Once in the host cell the viral DNA is released and integrates into the cell's genome. The advantage to this strategy is that the delivery of the DNA is very efficient. What is one possible problem of using a virus that can integrate into the human nuclear genome? Multiple Choice The virus carries genes that will interfere with host cell activities. The viral DNA sequences could still cause a disease. Since the viral DNA sequences no longer contain essential genes for viral replication the host cell may not be able to replicate either. The integration could disrupt an essential gene or genes.
Which of the following are the functions of reverse transcriptase in retroviruses? i) it hydrolyzes the host cell's DNA ii) it uses viral RNA as a template for DNA synthesis iii) it converts host cell RNA into viral DNA iv) it translates viral RNA into proteins v) It uses viral RNA as a template for making complementary RNA strand vi) It degrades RNA from DNA-RNA hybrid Oi, iv and v O ii, iv, v and vi ii and iii ii and vi
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What Is A Virus ? ; Author: Peekaboo Kidz;https://www.youtube.com/watch?v=YS7vsBgWszI;License: Standard YouTube License, CC-BY