Somatic hypermutation is characterized by a mutation of immunoglobulin (Ig) genes at higher rates compared to other genes. Somatic hypermutation become more evident when Ig genes are exposed second time to an immunizing agent. Somatic mutations occur only in the V regions of the rearranged light chain and heavy chain genes (producing B cells with mutated Ig receptors). Once, the B cell gets mutated, it competes for available antigen. By this way, a B cell with receptors having higher antigen binding affinity is selected than the initial B cell receptors. The affinity maturation mechanism is responsible for secondary immune response, which is stronger. Generation of potential antibodies (repertoire almost limitless) and generation of Ig diversity are the additional possibilities added by the affinity maturation process.

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Answer 1

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Chapter 26, Problem 6RQ

Summary Introduction

Somatic hypermutation is characterized by a mutation of immunoglobulin (Ig) genes at higher rates compared to other genes. Somatic hypermutation become more evident when Ig genes are exposed second time to an immunizing agent. Somatic mutations occur only in the V regions of the rearranged light chain and heavy chain genes (producing B cells with mutated Ig receptors).

Once, the B cell gets mutated, it competes for available antigen. By this way, a B cell with receptors having higher antigen binding affinity is selected than the initial B cell receptors. The affinity maturation mechanism is responsible for secondary immune response, which is stronger. Generation of potential antibodies (repertoire almost limitless) and generation of Ig diversity are the additional possibilities added by the affinity maturation process.

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Answer 2

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Chapter 26, Problem 6RQ

Summary Introduction

Somatic hypermutation is characterized by a mutation of immunoglobulin (Ig) genes at higher rates compared to other genes. Somatic hypermutation become more evident when Ig genes are exposed second time to an immunizing agent. Somatic mutations occur only in the V regions of the rearranged light chain and heavy chain genes (producing B cells with mutated Ig receptors).

Once, the B cell gets mutated, it competes for available antigen. By this way, a B cell with receptors having higher antigen binding affinity is selected than the initial B cell receptors. The affinity maturation mechanism is responsible for secondary immune response, which is stronger. Generation of potential antibodies (repertoire almost limitless) and generation of Ig diversity are the additional possibilities added by the affinity maturation process.

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Answer 3

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Chapter 26, Problem 6RQ

Summary Introduction

Somatic hypermutation is characterized by a mutation of immunoglobulin (Ig) genes at higher rates compared to other genes. Somatic hypermutation become more evident when Ig genes are exposed second time to an immunizing agent. Somatic mutations occur only in the V regions of the rearranged light chain and heavy chain genes (producing B cells with mutated Ig receptors).

Once, the B cell gets mutated, it competes for available antigen. By this way, a B cell with receptors having higher antigen binding affinity is selected than the initial B cell receptors. The affinity maturation mechanism is responsible for secondary immune response, which is stronger. Generation of potential antibodies (repertoire almost limitless) and generation of Ig diversity are the additional possibilities added by the affinity maturation process.

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Answer 4

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Chapter 26, Problem 6RQ

Summary Introduction

Somatic hypermutation is characterized by a mutation of immunoglobulin (Ig) genes at higher rates compared to other genes. Somatic hypermutation become more evident when Ig genes are exposed second time to an immunizing agent. Somatic mutations occur only in the V regions of the rearranged light chain and heavy chain genes (producing B cells with mutated Ig receptors).

Once, the B cell gets mutated, it competes for available antigen. By this way, a B cell with receptors having higher antigen binding affinity is selected than the initial B cell receptors. The affinity maturation mechanism is responsible for secondary immune response, which is stronger. Generation of potential antibodies (repertoire almost limitless) and generation of Ig diversity are the additional possibilities added by the affinity maturation process.

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Answer 5

Chapter 26, Problem 6RQ

Summary Introduction

Somatic hypermutation is characterized by a mutation of immunoglobulin (Ig) genes at higher rates compared to other genes. Somatic hypermutation become more evident when Ig genes are exposed second time to an immunizing agent. Somatic mutations occur only in the V regions of the rearranged light chain and heavy chain genes (producing B cells with mutated Ig receptors).

Once, the B cell gets mutated, it competes for available antigen. By this way, a B cell with receptors having higher antigen binding affinity is selected than the initial B cell receptors. The affinity maturation mechanism is responsible for secondary immune response, which is stronger. Generation of potential antibodies (repertoire almost limitless) and generation of Ig diversity are the additional possibilities added by the affinity maturation process.

Answer 6

Chapter 26, Problem 6RQ

Summary Introduction

Somatic hypermutation is characterized by a mutation of immunoglobulin (Ig) genes at higher rates compared to other genes. Somatic hypermutation become more evident when Ig genes are exposed second time to an immunizing agent. Somatic mutations occur only in the V regions of the rearranged light chain and heavy chain genes (producing B cells with mutated Ig receptors).

Once, the B cell gets mutated, it competes for available antigen. By this way, a B cell with receptors having higher antigen binding affinity is selected than the initial B cell receptors. The affinity maturation mechanism is responsible for secondary immune response, which is stronger. Generation of potential antibodies (repertoire almost limitless) and generation of Ig diversity are the additional possibilities added by the affinity maturation process.

Answer 7

Chapter 26, Problem 6RQ

Summary Introduction

Somatic hypermutation is characterized by a mutation of immunoglobulin (Ig) genes at higher rates compared to other genes. Somatic hypermutation become more evident when Ig genes are exposed second time to an immunizing agent. Somatic mutations occur only in the V regions of the rearranged light chain and heavy chain genes (producing B cells with mutated Ig receptors).

Once, the B cell gets mutated, it competes for available antigen. By this way, a B cell with receptors having higher antigen binding affinity is selected than the initial B cell receptors. The affinity maturation mechanism is responsible for secondary immune response, which is stronger. Generation of potential antibodies (repertoire almost limitless) and generation of Ig diversity are the additional possibilities added by the affinity maturation process.

Answer 8

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Answer 11

Ch. 26.1 - Prob. 1MQ Ch. 26.1 - Prob. 2MQ Ch. 26.2 - MINIQUIZ • Describe and compare the structural...Ch. 26.2 - Prob. 2MQ Ch. 26.3 - Prob. 1MQ Ch. 26.3 - Prob. 2MQ Ch. 26.4 - Prob. 1MQ Ch. 26.4 - Prob. 2MQ Ch. 26.5 - Prob. 1MQ Ch. 26.5 - Prob. 2MQ

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