Biochemistry (Looseleaf)
9th Edition
ISBN: 9781319114800
Author: BERG
Publisher: MAC HIGHER
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 28, Problem 12P
Interpretation Introduction
Interpretation:
The identification of approach for raising the Cyclic guanosine monophosphate (cGMP) levels that results in muscle relaxation with a small molecule Sildenafil should be determined.
Concept introduction:
Chemotherapy is a type of therapy in which a drug is used to cure any disease. Chemotherapy is a type of radiation therapy and surgery that is used to remove, kill, or damage cancer cells in some body part, but chemo can work all over the body.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Please help me with this question. PLEase give me the right answer and for number 2 WRITE AT LEAST A PARAGRAPGH and dont copy from internet.
Inducers and Inhibitors of AEP.
Short peptides such as legumain stabilization and activity modulation (LSAM) domain and αvβ3 integrin could enhance the activity of AEP. LSAM domain known as the prodomain of AEP blocks substrate binding before activation. This prodomain has a helical structure and two independent peptides. One is an activation peptide (AP, K287 to N323), and the other is a LSAM domain. LSAM domain remains even after AP is cleaved and released from protease at neutral pH via electrostatic interaction. AEP without LSAM domain has a lower melting temperature than AEP with LSAM domain [77, 117]. Another short peptide, αvβ3 integrin, can directly interact with AEP, and after forming a complex, the optimal pH for AEP activity is increased from 5.5 to 6.0. It indicates that αvβ3 binding could induce conformational stabilization of AEP accompanied by deprotonated C189. αvβ3 does not directly interact with the AEP active site; however, AEP docks to the αvβ3 RGD-binding site…
Not sure about both. Please help
Chapter 28 Solutions
Biochemistry (Looseleaf)
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Please help me with this question. More than one answer may be correct. THe graph relating to the information is included below. The above figures show the rate of actin polymerization in the presence of various concentration of profilin (Pfn). In the top figure, flourescence intensity is a measure of total actin that has been polymerized, and this is plotted versus time in seconds. The shade of blue of the lines in the top figure correspond to the shaded blue bars representing various concentrations of profilin in the lower figure. The lower graph shows the initial rates of polymerization of actin plotted again concentration. Which of the following is true: Question 21 options: profilin in a molecular motor profilin is a promoter of actin polymerization profilin replaced G-actin in an F-actin strand and breaks the filament profilin is an inhibitor of actin polymerization profilin binds to G-actin, preventing it from polymerizingarrow_forwardantidote for tetrodotoxin poisoning. First, what is the name of the made up drug? Second, describe the details of how the drug will work. description should contain details of how the drug will act at the cellular and/or molecular level.arrow_forwardNeed help. do explainarrow_forward
- Match the following. please be quick.arrow_forwardInsulin dependent diabetes is often accompanied by high levels of triacylglycerols in the blood. Suggest a biochemical explanation.arrow_forwardSpeed and efficiency matter. Acetylcholine is rapidly destroyed by the enzyme acetylcholinesterase. This enzyme, which has a turnover number of 25,000 per second, has attained catalytic perfection with a kcat/KMkcat / KM of 2×108 M-1s-1.2 × 10° M¯'s1. Why is the efficiency of this enzyme physiologically crucial?arrow_forward
- Need help with this. Also provided an explanation.arrow_forwardPLEASE DONT CANCEL. ILL UPVOTE WITH ALL OF MY ACCS. Make a drug study study about cetirizine (diphenhydramine hydrochloride) drug and fill up the corresponding details in the table. - The drug study shall be patient-based, and based on the informations provided below. - Nursing responsibilities would be in ADPIE form. MAIN DRUG: cetirizine (diphenhydramine hydrochloride) INFORMATIONS: Cetirizine Age: 18/F Occupation: Basketball player Weight and BMI: 50 KGS/22 Blood pressure: 100/70 Heart rate: 60 Respiratory rate: 15 Temperature: 36.2 Diagnosis: Allergic reaction with eating shrimp with facial angioedema Chief complaint: Swollen ears and mouth Prescription: Cetirizine PO 5 mg ODarrow_forwardCompared to the rectal and vaginal routes. If an active substance has a high logP, this constitutes a limiting factor for bioavailability when formulated in a hydrophobic base. Briefly explain why.arrow_forward
- Ligand binding and response. The following question involves the ligand binding to a receptor and the receptor's response to that ligand. What ligand concentration would be required for a full agonist with a KD of 8 nM to achieve a response of 0.75?arrow_forwardRespiratory paralysis. Tabun and sarin have been used as chemical-warfare agents, and parathion has been employed as an insecticide. What is the molec ular basis of their lethal actions? Tabun H3C Sarin -NO2 Parathionarrow_forwardThe Cori Cycle. Before vigorous exercise (at rest) the level of blood lactate is at its normal level (about 25 mM). During a 400 m sprint, the value rises sharply in less than a few minutes to about 200 mM and then declines slowly to around 40 mM over 60 mins after the sprint. a. Discuss (or illustrate) the pathway and reactions that cause the rapid increase in lactate concentration during the sprint. b. What causes the slow decline in lactate concentration after the sprint? Why does the decrease occur more slowly than the rapid increase? c. What enzymatic reaction is responsible for maintaining the lactate concentration above zero at recovery after the sprint?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning