   Chapter 3, Problem 13RE

Chapter
Section
Textbook Problem

# MATHEMATICAL An organic chemist is generally happy with 95% yields. If you synthesized a polypeptide and realized a 95% yield with each amino acid residue added, what would be your overall yield after adding 10 residues (to the first amino acid)? After adding 50 residues? After 100 residues? Would these low yields be biochemically “satisfactory”? How are low yields avoided, biochemically?

Interpretation Introduction

Interpretation:

The organic chemist is happy with 95% yields. The polypeptide is synthesized, and it is realized that with the addition of each amino acid residue, a 95% yield is obtained. The overall yield has to be determined after adding 10 residues, 50 residues, and 100 residues. Whether the low yields would be biochemically satisfactory or not is to be determined, and the mechanism by which low yield can be avoided is to be discussed.

Concept information:

Peptide bonds are the bonds formed between two amino acid residues. The bond is formed when the carboxyl end of one amino acid forms a bond with an amino group of another amino acid after the removal of water.

Polypeptides are defined as two or more amino acids bonded together.

Explanation

Given information:

The addition of one amino acid residue gives 95% of the yield.

The addition of one amino acid residue gives 95% of the synthesized polypeptide yield. By using the formula given below, the percentage of yield per amino acid residue added can be calculated.

Yield=(95100)10  = 60%

Where, n is the number of amino acid residues.

For 10 amino acid residues,

Yield=(95100)=(0.95)10  =60%

For 50 amino acid residues,

Yield =(95100)n=(0

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