Pearson eText Principles of Human Physiology -- Instant Access (Pearson+)
6th Edition
ISBN: 9780135213001
Author: Cindy Stanfield
Publisher: PEARSON+
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Chapter 3, Problem 28E
As you know, fatty acids can be oxidized to provide energy for making ATP. This process begins with a set of reactions known as the fatty acid oxidation cycle, or beta oxidation. Before entering the cycle, a fatty acid reacts with coenzyme A to form a molecule called fatty acyl CoA. This molecule then enters the cycle and continues to go through it until all its carbons have been eliminated, as shown on the following page. From your examination of this diagram, answer the following questions for a 1 2-carbon fatty acid.
- How many acetyl CoA molecules will be produced by beta oxidation of this fatty acid? How many ATP molecules can be produced from each acetyl CoA molecule that goes through the Krebs cycle and oxidative phosphorylation?
- How many NAD+ and FAD molecules will be reduced? (Hint: How many bonds must be broken to split a 12-carbon fatty acid into acetyl CoA molecules?)
- How many ATP molecules will be produced per each NADH + H+ and each FADH2 molecule that provides electrons to the electron transport system?
- It takes two ATP molecules to get the cycle started. Based on this information and your answers to the previous questions, how many ATP molecules can be generated from a 1 2-carbon fatty acid?
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Chapter 3 Solutions
Pearson eText Principles of Human Physiology -- Instant Access (Pearson+)
Ch. 3.1 - What is the primary distinction between an...Ch. 3.1 - Describe in general terms what occurs in...Ch. 3.2 - In an exergonic reaction, which has more...Ch. 3.2 - Which factor determines the direction of a...Ch. 3.2 - Prob. 3.2.3QCCh. 3.2 - What is activation energy? How does it affect a...Ch. 3.3 - Prob. 3.3.1QCCh. 3.3 - How is the rate of an enzymatic reaction affected...Ch. 3.3 - What is the primary distinction between allosteric...Ch. 3.5 - Prob. 3.4.1QC
Ch. 3.5 - Prob. 3.4.2QCCh. 3.5 - Prob. 3.4.3QCCh. 3.6 - Prob. 1CTQCh. 3.6 - Prob. 2CTQCh. 3.6 - Prob. 3CTQCh. 3.6 - Prob. 3.5.1QCCh. 3.6 - Prob. 3.5.2QCCh. 3.6 - Prob. 3.5.3QCCh. 3.6 - Prob. 3.5.4QCCh. 3.7 - Prob. 3.6.1QCCh. 3.7 - Prob. 3.6.2QCCh. 3.7 - Prob. 3.6.3QCCh. 3 - Prob. 1ECh. 3 - Prob. 2ECh. 3 - Prob. 3ECh. 3 - Prob. 4ECh. 3 - Prob. 5ECh. 3 - Prob. 6ECh. 3 - Prob. 7ECh. 3 - Prob. 8ECh. 3 - Prob. 9ECh. 3 - Prob. 10ECh. 3 - The removal of hydrogen atoms from a molecule is...Ch. 3 - Prob. 12ECh. 3 - Prob. 13ECh. 3 - Prob. 14ECh. 3 - Prob. 15ECh. 3 - Prob. 16ECh. 3 - Prob. 17ECh. 3 - Prob. 18ECh. 3 - Prob. 19ECh. 3 - Prob. 20ECh. 3 - Prob. 21ECh. 3 - Prob. 22ECh. 3 - Prob. 23ECh. 3 - Compare and contrast the mechanisms of...Ch. 3 - Explain how the conversion of pyruvate to lactate...Ch. 3 - Prob. 26ECh. 3 - Prob. 27ECh. 3 - As you know, fatty acids can be oxidized to...Ch. 3 - Prob. 29E
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- When the acetyl-CoA produced during β-oxidation in the liver exceeds the capacity of the citric acid cycle, the excess acetyl-CoA forms ketone bodies—acetone, acetoacetate, and D-b-hydroxybutyrate. This occurs in severe, uncontrolled diabetes: because the tissues cannot use glucose, they oxidize large amounts of fatty acids instead. Although acetyl-CoA is not toxic, the mitochondrion must divert the acetyl-CoA to ketone bodies. What problem would arise if acetyl-CoA were not converted to ketone bodies? How does the diversion to ketone bodies solve the problem?arrow_forwardThe citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options except citrate. Which carbon in citrate will contain C14? 4 1 3 2 Which carbon(s) in isocitrate will contain C14? 1 2 3 4 5 6 Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4arrow_forwardThe conversion of pyruvate to Acetyl-CoA involves an oxidative decarboxylation. Correct the path of the electrons through this mechanism: Pyruvate -> NAD -> lipoamide -> FAD -> TPParrow_forward
- Fourteen NADPH molecules are required to produce one molecules of palmitic acid from acetyl CoA. Substantiate this statement by referring to the enzymatic activities involved in reduction steps during fatty acid synthesis and the number of cycles required to produce palmitic acid from acetyl CoA. How many molecules of ATP is required for the synthesis of palmitic acid from cytosolic acetyl-CoA?arrow_forward3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) is a very long name for the enzyme that is involved in the production of cholesterol in the human liver. The enzyme catalyzes a reaction in which electrons are exchanged between reactants to form products. This an example of which of the following chemical reactions that are involved in maintaining homeostasis? HMG-CoA reductase catalyzes a catabolic reaction because electrons are exchanged between the reactants to form products. HMG-CoA reductase catalyzes a specific type of exchange reaction called an oxidation-reduction reaction in which electrons are exchanged between reactants to form products. HMG-CoA reductase catalyzes an anabolic reaction because electrons are exchanged between the reactants to form products. HMG-CoA reductase catalyzes a specific type of oxidation-reduction reaction called an exchange reaction in which atoms are exchanged between reactants to form products. Like most enzymes, HMG-CoA reductase…arrow_forwardTwo carbon atoms are fed into the citric acid cycle as acetyl-CoA. In what form are two carbon atoms removed from the cycle?arrow_forward
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