Pushing Electrons
Pushing Electrons
4th Edition
ISBN: 9781133951889
Author: Weeks, Daniel P.
Publisher: Cengage Learning
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Offer an explanation for the observation that 4-chloropyridine is more reactive toward nucleophiles than 3-chloropyridine.
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The Reformatsky reaction is an addition reaction in which an organozinc reagent is used instead of a Grignard reagent to add to the carbonyl group ofan aldehyde or a ketone. Because the organozinc reagent is less reactive than a Grignard reagent, a nucleophilic addition to the ester group does not occur.The organozinc reagent is prepared by treating an a-bromo ester with zinc. Describe how each of the following compounds can be prepared, using a Reformatsky reaction:
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