Pushing Electrons
4th Edition
ISBN: 9781133951889
Author: Weeks, Daniel P.
Publisher: Cengage Learning
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Offer an explanation for the observation that 4-chloropyridine is more reactive toward nucleophiles than 3-chloropyridine.
Draw a structural formula for the product formed by treating reactants with sodium ethoxide in ethanol under conditions of the Michael reaction.
The Reformatsky reaction is an addition reaction in which an organozinc reagent is used instead of a Grignard reagent to add to the carbonyl group ofan aldehyde or a ketone. Because the organozinc reagent is less reactive than a Grignard reagent, a nucleophilic addition to the ester group does not occur.The organozinc reagent is prepared by treating an a-bromo ester with zinc.
Describe how each of the following compounds can be prepared, using a Reformatsky reaction:
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