Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 31, Problem 6P
Interpretation Introduction
Interpretation:
The different covalently modified forms of acetyl-CoA carboxylase protein that are possible if there are seven phosphorylation sites needs to be determined.
Concept Introduction:
Acetyl-CoA carboxylase is the enzyme which is biotin-dependent that is used to catalyze the irreversible carboxylation of the acetyl CoA to yield malonyl-CoA by its 2 catalytic actions, carboxyltransferase and biotin carboxylase.
Expert Solution & Answer
Trending nowThis is a popular solution!
Students have asked these similar questions
Properties of an Enzyme of Prostaglandin Synthesis.Prostaglandins are a class of eicosanoids, fatty acid derivatives with a variety of extremely potent actions on vertebrate tissues. They are re-sponsible for producing fever and inflammation and its associated pain. Prostaglandins are derived from the 20-carbon fatty acid arachidonic acid in a reaction catalyzed by the enzyme prostaglandin en-doperoxide synthase. This enzyme, a cyclooxygenase, uses oxygen to convert arachidonic acid to PGG2, the immediate precursor of many different prostaglandins (prostaglandin synthesis is described in Chapter 21).
a)The kinetic data given below are for the reaction catalyzed by prostaglandin endoperoxide synthase. Focusing here on the first two columns, determine the Vmax and Km of the enzyme.
b)Ibuprofen is an inhibitor of prostaglandin endoperoxide synthase. By inhibiting the synthesis of prostaglandins, ibuprofen reduces inflammation and pain. Using the data in the first and third columns of…
biosynthesis of Thymidine monophosphate from ATP, HCO3-, Gln, Asp, quinone, and methylene THF. Show your work and don’t forget that the conversion of U to T only happens AFTER Ribonucleotide Reductase processes the 2’, 3’ ribose to the 3’ deoxy ribose
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Modeling the Regulation of AcetyI-CoA Carboxylase Based on the information presented in the text and in Figures 24.4 and 24.5, suggest a model for the regulation of acetyl-CoA carboxylase. Consider the possible roles of subunit interactions, phosphorylation, and conformation changes in your model.arrow_forwardUnderstanding the Oxidation of Glucose and Its Products in the TCA Cycle Glycolysis, the pyruvate dehydrogenase reaction, and the TCA cycle result in complete oxidation of a molecule of glucose to CO2. Review the calculation of oxidation numbers for individual atoms in any molecule, and then calculate the oxidation numbers of the carbons of glucose, pyruvate, the acetyl carbons of acetyl-CoA. and the metabolites of the TCA cycle to convince yourself that complete oxidation of glucose involves removal of 24 electrons and that each acetyl-CoA through the TCA cycle gives up 8 electrons.arrow_forwardRegulation of Glutamine Synthetase by Covalent Modification Suppose at certain specific metabolite concentrations in vivo the cyclic cascade regulating E. coli glutamine synthetase has reached a dynamic equilibrium where the average state of GS adenylylation is poised atn=6. Predict what change in nwill occur if: [ ATP ] increases, PIIA/PIID increases, [ -KG ]/[ Gln ] increases, [ Pi ] decreases.arrow_forward
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY