BIO.SCI.UDEL.VOL1.(LL)W/ACCESS REV >IB
17th Edition
ISBN: 9781323780305
Author: Freeman
Publisher: PEARSON C
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Chapter 32, Problem 13PIAT
Gene expression patterns can be used to test hypotheses based on morphology. For example, the regulatory gene Bapxl is expressed in the hinge of the developing lower jaw in fishes and reptiles. Where would you predict Bapxl expression to occur in mammals?
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given a situation in which you manipulated a zebrafish embryo by injecting high levels of retinoic acid so that no anterior genes will be expressed. Surprisingly, after embryonic development, you are still able to observed the presence of anterior structures. What could explain this observation? What changes in your experiment would you make to achieve your objective?
The homeotic mutation Antennapedia causes mutant Drosophila to have legs in place of antennae and is a dominant gain-of-function mutation. List all the properties of such mutations. How does the Antennapedia gene change antennae into legs?
Pax6 is a gene that is involved in mammalian eye development. Mutations in this gene result in a lack of iris in humans, and mice that are homozygous for the mutation lack eyes completely. Mutations in the eyeless gene in the fruitfly Drosophila result in reduced eyes. Expressing Pax6 from mammals in other tissues of Drosophila during its embryonic development can result in an ectopic eye (e.g. an eye expressed in a different tissue type). An example of an ectopic eye on the antenna of Drosophila is shown below.
Part A:
The eye of humans, mouse, and fly are an example of the following (check all that apply)
A. Structural analog
B. Structural homolog
C. Developmental homolog
D. Genetic homolog
Part B:
Darwin's hypothesis of natural selection has two components:
Species are not static but change through time
Species are related, and not independent.
In what ways does the human, mouse, and fly eye support or contradict one or both of the two components of…
Chapter 32 Solutions
BIO.SCI.UDEL.VOL1.(LL)W/ACCESS REV >IB
Ch. 32 - True or false? Both echinoderms and vertebrates...Ch. 32 - 2. What trait(s) define(s) the vertebrates?
a....Ch. 32 - The two major lineages that make up the living...Ch. 32 - Most species of hominins are known only from...Ch. 32 - Mammals and birds are both endothermic. Which...Ch. 32 - MODEL Sketch a simple model of a generic chordate...Ch. 32 - 7. There is some evidence that pharyngeal slits...Ch. 32 - MODEL Draw a phylogeny of modem humans that would...Ch. 32 - 9. Consider the evolution of protostomes (Chapter...Ch. 32 - 10. MODEL Genetic diversity in living human...
Ch. 32 - Prob. 11PIATCh. 32 - CAUTION How is the opossum related to you? a. An...Ch. 32 - 13. Gene expression patterns can be used to test...Ch. 32 - 14. PROCESS OF SCIENCE Researchers studied mice...Ch. 32 - 15. The image of the opossum skull shows that the...Ch. 32 - Evolution often results in the co-option of a...
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- Another way to study the role of proteins (e.g., transcription factors) that function in development is to microinject the mRNA that encodes a protein, or the purified protein itself, into an oocyte or embryo, and then determine how this affects the subsequent development of the embryo, larva, and adult. For example, if Bicoid protein is injected into the posterior region of an oocyte, the resulting embryo will develop into a larva that has anterior structures at both ends. Based on your understanding of the function of each developmental gene, what would be the predicted phenotype if the following proteins or mRNAs were injected into normal oocytes? A. Nanos mRNA injected into the anterior end of an oocyte B. Antp protein injected into the posterior end of an embryo C. Toll mRNA injected into the dorsal side of an early embryoarrow_forwarddescribe the arrangment of Hox genes on each chromosome in mammals in relation to their expression pattern. What effect would you expect if you expressed a Hox gene more anterior to its normal expression domain?arrow_forwardMatch the following transcription factors whose expression during embryonic development leads to the key segments or axes of the vertebrate limb. Heart and neural crest derivatives expressed 2 (Hand2) A. late expression in the limb bud gives rise to the autopod v Meis B. temporally intermediate expression in the limb bud gives rise to the zeugopod v Homeobox a11 (Hoxa11) C. early expression in the limb bud gives rise to the stylopod v Homeobox a13 (Hoxa13) D. Expressed as a morphogenetic gradient to establish the anteroposterior axis of the developing limb budarrow_forward
- You hope to study a gene that codes for a neurotransmitter protein produced in human brain cells. You know the amino acid sequence of the protein. Explain how you might (a) identify what genes are expressed in a specific type of brain cell, (b) identify (and isolate) the neurotransmitter gene, (c) produce multiple copies of the gene for study, and (d) produce large quantities of the neurotransmitter for evaluation as a potential medication.arrow_forwardBriefly explain the transcriptional regulation of mammalian gene expression? Please explain at your own words.arrow_forwardDominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development. (a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer. (b) What evidence indicates that the eyeless gene is part of a developmental network?arrow_forward
- Signal transduction pathways are important mechanisms for cell-to-cell communication in multicellular organisms. How do the target cells typically respond when they receive signals from neighboring cells during very early stages of embryo development? A. The target cells move to one of the poles to establish the anterior-posterior body axis. B. The target cells undergo changes in gene expression, sending them down a specific developmental path. C. The target cells stop dividing so the neighboring cells have time to get to the same stage of development. D. The target cells activate a collection of miRNAs to accelerate transcription and cell division.arrow_forwardSuppose you want to determine whether a particulargene X is important for specification of the pharynx,but mutations in this same gene disrupt embryonicdevelopment well before pharyngeal structures appear.How could you use myo-2::GFP, the myo-2 promoter,the DNA sequence of gene X, and your knowledge ofRNA interference (RNAi) to generate worms that lackgene X expression in the pharynx but express gene Xin all other tissues in which it is expressed in wildtype C. elegans?arrow_forwardDominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development. (a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer. (b) What evidence indicates that the eyeless gene is part of a developmental network? (c) Are genetic networks likely to specify developmental processes in general? Explain fully and provide an example.arrow_forward
- The Drosophila homeotic mutation spineless aristapedia (ssa ) results in the formation of a miniature tarsal structure (normally part of the leg) on the end of the antenna. What insight is provided by (ssa ) concerning the role of genes during determination?arrow_forwardWhat is positional information? Discuss three different ways that cells obtain positional information. Which of these three ways do you think is the most important for the formation of a segmented body pattern in Drosophila?arrow_forwardThe MyoD gene in mammals plays a role in skeletal muscle-cell differentiation, whereas the Hox genes are homeotic genes that play a role in the differentiation of particular regions of the body. Explain how the functions of these genes are similar and different.arrow_forward
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QCE Biology: Introduction to Gene Expression; Author: Atomi;https://www.youtube.com/watch?v=a7hydUtCIJk;License: Standard YouTube License, CC-BY