EBK EXPERIMENTAL ORGANIC CHEMISTRY: A M
6th Edition
ISBN: 9781305687875
Author: Gilbert
Publisher: CENGAGE LEARNING - CONSIGNMENT
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Use a suitable model to explain how separation and identification of a mixture of organic compounds can be achieved with a thin layer chromatographic (TLC) technique.
Of Aspirin, ethanol, acetaminophen, ethyl acetate, hexane, and water which could go undetected during HPLC analysis, but could result in a lower than expected melting point, why are they not detected by HPLC analysis?
TLC was used to compare the solubility of two compounds A and B in a solvent system (acetic acid, methanol, H2O). The distances that solvent has moved in the silica gel TLC was 12 cm. and for the compounds were 2 and 8 cm respectively. (a) Calculate the Rf values and which compound is more soluble and which one is more polar. (b) What are the factors affecting the Rf value
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- 1. What is paper chromatograpy?2. What are the stationary phase and mobile phase in paper chromatograpy?3. What is the principle underlying the paper chromatograpy?4. What is Rf value of a dye or pigment?5. Would you expect that changing the solvent will change the Rf value of the specific solute? Why?6. Suggest simple reasons why the Ni2+ and Fe3+ ions have different Rf values?7. What forces causes the eluting solution to move the chromatographic support material?arrow_forwardWhich statement about the determination of the percentage purity of benzoic acid is correct? * A- Only sodium hydroxide solution can be used as the titrant in the volumetric analysis of benzoic acid. B- Analysing a benzoic acid sample that still contains some hydrochloric acid may yield an analyte percentage that is less than expected. C- Analysing a wet benzoic acid sample may yield an analyte percentage that is more than expected. D- All these statements are correct. E- None of these statements are correct.arrow_forwardIn TLC chromatography there is a technique known as Co-spotting. In this technique, a sample of an unknown substance is charged at the same point, together with a known substance and stimulated by some kind of stimulant. In the example below, we loaded biphenyl (a known substance) together with two unknown substances A and B. Is A, or B biphenyl? Justify your answer. What is the alternative method to co-spotting, and which one do you think is better?arrow_forward
- 1. How does chromatography separate the components of leave samples? 2. Can you use chromatography to purify a mixture? why? 3. What is Rf value and its significance in chromatography?arrow_forwardThe three TLC plates below show the analysis of the same mixture of two compounds. One plate was developed in 100% DCM, one in 90:10 DCM/MeOH, and one in 80:20 DCM/MeOH. Determine which plate was developed in which solvent.arrow_forwardWhich statement is true? Statement 1: In chromatography, the compound mixture moves along with the mobile phase through the stationary phase and the components get separated depending on the degree of interaction and adhesion Statement 2: Compound A is more soluble in the mobile phase compared to compound B. Thus, compound A would most probably have a higher Rf value.arrow_forward
- Which statement about TLC analyses is not true? * A- The line at the base of the TLC plate should be drawn with a pencil. B- To prevent contamination, a new capillary tube should be used to apply each sample. C- Samples should be applied multiple times in the same place to increase the concentrations of any possible compounds in the spot. D- A glass beaker lined with filter paper can be used as a development chamber in a TLC analysis. E- All these statements are correct.arrow_forwardDifferentiate normal phase chromatography from reverse phase chromatography. From which of the two in TLC and paper chromatography is normal phase chromatography and reverse phase chromatography? How do you say so?arrow_forwardNeed help with a and b. A mixture of 1-hexanol, hexane, and 1-chlorohexane is injected on a gas chromatography column. a) Predict the sequence of retention times indicating which compound will have the shortest, middle, and longest retention time. b) The sample vial of (a) was not carefully sealed and left partially open for a couple hours. A GC is taken again with only two peaks realized. The first peak to appear has an area of 24 mm2 and the second peak 40 mm2. What mole% of each compound (specify the compound name) is most likely present?arrow_forward
- Indicate whether TLC (thin-layer chromatography) or column chromatography is more appropriate for the following:a. This is an analytical method for separating compounds of amixture.b. The solvent front moves downward.c. This is a preparative method for separating a mixture ofcompounds.arrow_forwardHow can TLC be used to determine if a sample is pure?arrow_forwardBelow are the gas chromatography results of two separate distillations of the same 1:1 mixture of ethanol and 1-butanol. One sample was obtained from the first fraction of a simple distillation and one sample was obtained from the first fraction of a fractional distillation. Identify the peaks in the chromatographs. Discuss the conclusions you can make regarding simple distillation compared with fractional distillation. Which method was more successful?arrow_forward
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