PRESCOTT'S MICROBILOGY
11th Edition
ISBN: 9781264075515
Author: WILLEY
Publisher: MCG
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Chapter 33.7, Problem 3MI
Summary Introduction
When a person is exposed to an antigen, for example, an infection or vaccine, there is an initial
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Shortly after the recovery from COVID-19, the
plasma of the convalescent has significant
quantities of anti-SARS-CoV-2 antibodies. This
plasma was suggested to be used as therapy
for other COVID-19 patients by transfusing the
plasma from the recovered individuals (donor)
to the other COVID-19 patients (recipient). Do
you think the identification of the ABO group of
the donor and recipient is important and why?
O a. No, this has nothing to do with blood
grouping. It is only related to the virus and
the antibodies against it.
O b. Yes, but I really have no idea why.
O c. No, not important because the antigens A,
B or AB exist on the surface of red blood
cells but not in the plasma and when they
transfer, they do not transfer cells (only
plasma)
O d. Yes, because the donor plasma might
contain anti-A or Anti-B or both which
might induce an immune response if the
recipient has A or B or AB group.
Clear my choice
What is the difference in the kinetics of antibody formation in response to a dirst and second exposure to the same antigen?
Addition of immunoglobulin G (IgG) specific for hemoglobin to a solution of hemoglobin results in the formation of a red
precipitate. In contrast, addition of the Fab fragments from this antibody to hemoglobin results in no such precipitate.
What could explain this difference in results?
Treatment with papain produces Fab fragments with different antigen specificity than the original IgG molecule.
IgG can simultaneously bind two different antigens, whereas an Fab fragment can only bind one antigen at a time.
The Fab fragments preferentially bind to other Fab fragments rather than to hemoglobin.
The hemoglobin molecule antibody-binding sites can bind IgG molecules, but cannot bind Fab fragments.
Chapter 33 Solutions
PRESCOTT'S MICROBILOGY
Ch. 33.2 - What does the term valence mean and how does an...Ch. 33.2 - Prob. 1CCCh. 33.2 - Prob. 2CCCh. 33.2 - Prob. 3CCCh. 33.3 - What distinguishes natural from artificial...Ch. 33.3 - What are ways that active immunity is different...Ch. 33.3 - Of the four types of acquired immunity, which do...Ch. 33.4 - On what types of cells are MHC class I molecules...Ch. 33.4 - Prob. 2MICh. 33.4 - Prob. 1CC
Ch. 33.4 - Prob. 2CCCh. 33.4 - Prob. 3CCCh. 33.5 - Prob. 1MICh. 33.5 - Prob. 1CCCh. 33.5 - Prob. 2CCCh. 33.5 - Prob. 3CCCh. 33.5 - Prob. 4CCCh. 33.5 - Prob. 5CCCh. 33.5 - Prob. 6CCCh. 33.6 - Prob. 1MICh. 33.6 - Prob. 1CCCh. 33.6 - Prob. 2CCCh. 33.6 - Prob. 3CCCh. 33.7 - Prob. 1MICh. 33.7 - Prob. 2MICh. 33.7 - Prob. 3MICh. 33.7 - Prob. 1CCCh. 33.7 - Prob. 2CCCh. 33.7 - Prob. 3CCCh. 33.7 - Prob. 4CCCh. 33.7 - Prob. 5CCCh. 33.7 - Prob. 6CCCh. 33.8 - What is the difference between a precipitation and...Ch. 33.8 - Prob. 1CCCh. 33.8 - Prob. 2CCCh. 33.8 - Prob. 3CCCh. 33.9 - Prob. 1CCCh. 33.9 - Prob. 2CCCh. 33.10 - Prob. 1MICh. 33.10 - Prob. 2MICh. 33.10 - Prob. 1.1CCCh. 33.10 - Prob. 1.2CCCh. 33.10 - Prob. 1.3CCCh. 33.10 - Prob. 1.4CCCh. 33.10 - What is an autoimmune disease and how might it...Ch. 33.10 - Prob. 2.2CCCh. 33.10 - Prob. 2.3CCCh. 33.10 - Prob. 2.4CCCh. 33 - Prob. 1RCCh. 33 - Prob. 2RCCh. 33 - Prob. 3RCCh. 33 - Prob. 4RCCh. 33 - Prob. 5RCCh. 33 - Prob. 1ALCh. 33 - Prob. 2ALCh. 33 - Prob. 3ALCh. 33 - Prob. 4ALCh. 33 - Prob. 5AL
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- Surprisingly, humans as well as mice deficient in the complement protein, C3, have greatly reduced antibody responses to T cell-dependent antigens, and are impaired in their ability to control HSV infections. When C3-deficient mice are infected with HSV, once at day 0 and then a second time 4 weeks later, their antibody response is altered compared to wild-type mice, as shown in the figure #3 below. a) What is a likely explanation for the altered antibody response in the absence of complement C3? For fugure #4: For this experiment, mice are infected with varying doses of the HSV-rd virus, and peak IgG responses to the viral surface glycoproteins are measured. The results are shown in the fugure #4. b) What is the most likely explanation for these data? Do these results impact your answer to the part above (a)? Explain your reasoning.arrow_forwardT cells can differentiate into 5 different subsets of helper T cells. Answer the following questions for TH1 cells: A) In general, list three unique factors that differentiate the TH1 subset from the other subsets. B) For each of those factors identified in A, provide one specific example that applies to TH1 cells. C) What type of pathogens are targeted by the TH1 cells?arrow_forwardHow do intracellular microorganisms stimulate cytotoxicT cells? What role do helper T cells play in this process?arrow_forward
- If antibody responses are not elicited by a Covid-19 vaccine, are there other types of immune response that could provide protection from the SARS-Co-V2 virus following vaccination? Explain why or why not.arrow_forwardShortly after the recovery from COVID 19, the plasma of the convalescent has significant quantities of anti - SARS CoV - 2 antibodies. This plasma was suggested to be used as therapy for other COVID - 19 patients by transfusing the plasma from the recovered individuals (donor) to the other COVID 19 patients (recipient). Do you think the identification of the ABO group of the donor and recipient is important and why?arrow_forwardOne strategy for preventing type 1hypersensitivity is to induce plasma cells tosecrete lgG instead of IgE. Why would this blockallergy symptoms?arrow_forward
- CD8 T cells in a culture are analyzed for their ability to produce the cytokine IFN-g, and the numbers of IFN-g-producing CD8 T cells are quantified. As a control, T cells are also stimulated with an irrelevant non-viral peptide (ova) plus dendritic cells. The results are shown in the figure below. Why is the T cell response different between the two lymph node populations?arrow_forwardHow does thrombin catalyze the formation of loose fibrin and help in the activation of factor XIII?arrow_forwardWhy is CRP measured when inflammation is suspected? give references.arrow_forward
- Does the level of antibody in your serum directly relate to how well you are protected from another exposure to COVID-19? If you have lower levels of antibody, does that mean you are more likely to get sick again in the future?arrow_forwardWhat can you conclude from the amino acid properties and movement on the TLC plate?arrow_forwardWhat is an immunoglobulin? Describe the structure of an immunoglobulin molecule (light chain and heavy chain).arrow_forward
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