The feasibility of treating septic shock with the drug that blocks the TLR signaling using mutated mice that has mutation that cause the inactivation of the TLR gene and purified LPS. Introduction: TLR are the toll like receptors that are involved in the septic shock of the body that is induced by the lipopolysaccharides (LPS) of the gram negative bacteria when it is introduced into the blood. The TLR are the reason for the septic shock.

Question

Want to see the full answer?

Answer 1

Question

Chapter 35, Problem 8TYU

Summary Introduction

To determine:

The feasibility of treating septic shock with the drug that blocks the TLR signaling using mutated mice that has mutation that cause the inactivation of the TLR gene and purified LPS.

Introduction:

TLR are the toll like receptors that are involved in the septic shock of the body that is induced by the lipopolysaccharides (LPS) of the gram negative bacteria when it is introduced into the blood. The TLR are the reason for the septic shock.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

Immune systems of animals are very complex. For an animal's immune system to work properly, certain cells must be able to recognize other specific types of cells, so that they can bind to and communicate with them. These types of interactions allow an immune system to decide if and when to launch an immune response. For example, dendritic cells must be able to recognize and interact with T-cells, but they do not need to recognize adipocyte cells. Which of the following describes a difference between T-cells and adipocyte cells that would allow dendritic cells to recognize one, but not the other? A. Adipocyte cells must have a cell wall, while T-cells lack one. B. T-cells and adipocyte cells must have different types of lipids that compose their plasma membranes. C. Adipocyte cells must lack endoplasmic reticulum, while T-cells possess endoplasmic reticulum. D. T-cells and adipocyte cells must have some differences in the carbohydrates and/or…

a major cause of septic shock is the presence of lipopolysaccharide (LPS) from bacteria in the blood. suppose you have available purified LPS and several strain of mice, each with a mutation that inactivates a particular TLR gene. How might you use these mice to test the feasibility of treating septic shock with a drug that blocks TLR signaling?

Which of the following is true about innate immune system? Check all that apply. PAMPs recognize pathogen recognition receptors (PRRs) such as TLRs, NLRs and RLRs present on/in host cells TLRs that are expressed on cell surface are mostly recognized by viruses, whereas intracellular TLRs are recognized by bacteria PRRs can induce inflammatory response, opsonization and phagocytosis Pattern associated molecular patterns (PAMPs) are molecules such as CpG DNA, cytosolic dsDNA and RNAs made by the host cell