Figure 37.5 Heat shock proteins (HSP) are so named because they help refold misfolded proteins. In response to increased temperature (a “heat shock"), heat shock proteins are activated by release from the NR/HSP complex. At the same time, transcription of HSP genes is activated. Why do you think the cell responds to a heat shock by increasing the activity of proteins that help refold misfolded proteins?
To write:
The reasons behind the cell response to a heat shock to increase the activity of proteins that help refold misfolded proteins.
Introduction:
Heat shock proteins are the proteins, which act as the molecular chaperons. These are only produced in the cells when the cells undergo the stressed conditions. They play the functions in stabilizing the proteins and ensure the folding and refolding of the proteins.
Explanation of Solution
HSPs regulate the process of transcription. When the cell faced any stressed conditions, the intracellular nuclear receptor bond to these heat shock proteins and gets dissociated from the heat shock proteins upon hormone binding. This nuclear receptor and heat shock protein complexes activate the heat shock proteins and the process of transcription and translation take place.
After this, the hormone receptor complex binds a DNA sequence in the nucleus and form hormone response element. This element functions in initiating the process of gene transcription and translation and the resulting corresponding protein product will regulate the changes functions of cells. In case of high temperature, the structure of the protein gets unfold or get denature.
In case of high temperature, the proteins structure get unfold or get denature.
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