BROOKER BIOLOGY
BROOKER BIOLOGY
5th Edition
ISBN: 9781307656152
Author: BROOKER
Publisher: MCG/CREATE
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Chapter 42.4, Problem 1EQ

What key prior observation led Loewi to develop his hypothesis of how nerves stimulate or inhibit heart muscle contractions?

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The tetanus toxin tetanospasmin blocks release of the neurotransmitter (GABA) that inhibits motor neurons and decreases muscle contraction. This causes persistence of the signal to contract and the resulting violent muscle contraction known as tetanic spasm. Compare the sustained contraction of muscle cells in rigor mortis with muscle contraction caused by the action of tetanospasmin on motor neurons. Describe experiments using marker molecules that have been done to elucidate important properties of (1) tight junctions and (2) gap junctions, and propose one additional experiment you could do with each junction to gain a greater understanding of that junction's properties.
Can you modify this experiment so that the mass lifted by the muscle contraction continues to increase for every trial? If yes, explain how it should be modified. If no, explain why.
The experiment that crossed the nerve from a muscle that had a short contraction time "a fast muscle" to a muscle with a slower contraction profile and from the slower muscle to the faster muscle demonstrated that the nerve or activity of the muscle had no effect on properties of the muscle fibers.  a.) True b.) False

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