Biology Concepts and Connections Custom Edition for Everett College
2nd Edition
ISBN: 9781269968904
Author: Campbell
Publisher: PEARSON C
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Chapter 43, Problem 8TYU
Summary Introduction
To draw: The antibody-linking protein complex that could trigger endocytosis by a macrophage.
Introduction: An antigen is a large molecule. It may be made up of proteins or polysaccharides. A single antigen has several binding sites that are called epitopes. Each antibody binds to a specific epitope of an antigen. An antibody is a Y-shaped protein molecule that consists of four polypeptide chains. There are two identical heavy chains and two identical light chains connected by a disulfide bond. Antibody binds to the antigen receptor of pathogens like bacteria or virus.
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Consider a pencil-shaped protein with two epitopes, Y (the “eraser” end) and Z (the “point” end). They are recognized by antibodies A1 and A2, respectively. Draw and label a picture showing the antibodies linking proteins into a complex that could trigger endocytosis by a macrophage.
DRAW IT Sketch a B cell antigen receptor. Label the Vand C regions of the light and heavy chains. Label theantigen-binding sites, disulfide bridges, and transmembrane region. Where are these features located relativeto the V and C regions?
Draw a schematic diagram of a typical IgG molecule and label each of the following parts: H chains, L chains, intrachain disulfide bonds, hinge, Fab, Fc, and all the domains. Indicate which domains are involved in antigen binding.
Chapter 43 Solutions
Biology Concepts and Connections Custom Edition for Everett College
Ch. 43.1 - Pus is both a sign of infection and an indicator...Ch. 43.1 - MAKE CONNECTIONS How do the molecules that...Ch. 43.1 - Prob. 3CCCh. 43.2 - Prob. 1CCCh. 43.2 - Prob. 2CCCh. 43.2 - WHAT IF? If both copies of a light-chain gene and...Ch. 43.3 - Prob. 1CCCh. 43.3 - Treatment of antibodies with a particular protease...Ch. 43.3 - Prob. 3CCCh. 43.4 - Prob. 1CC
Ch. 43.4 - Prob. 2CCCh. 43.4 - WHAT IF? How would a macrophage deficiency likely...Ch. 43 - In what ways does innate immunity protect the...Ch. 43 - Why is the adaptive immune response to an initial...Ch. 43 - Is immunological memory after a natural infection...Ch. 43 - Prob. 43.4CRCh. 43 - Prob. 1TYUCh. 43 - An epitope associates with which part of an...Ch. 43 - Prob. 3TYUCh. 43 - Level 2: Application/Analysis 4. Which of the...Ch. 43 - Prob. 5TYUCh. 43 - Prob. 6TYUCh. 43 - Prob. 7TYUCh. 43 - Prob. 8TYUCh. 43 - MAKE CONNECTIONS Contrast clonal selection with...Ch. 43 - EVOLUTION CONNECTION Describe one invertebrate...Ch. 43 - Prob. 11TYUCh. 43 - Prob. 12TYUCh. 43 - SYNTHESIZE YOUR KNOWLEDGE This photo shows a child...
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- Based on the constant region of the antibodies there are only five iso-types of the antibodies, while millions of different Variable region domains in the variable part of the antibodies. why?arrow_forwardThere are five major classes of antibodies. Complete the two below.arrow_forwardIllustrate the structure of an antibody molecule. Label the constant and variable regions, the Fc and Fab parts, and the heavy and light chains.arrow_forward
- There are five major classes of antibodies. Complete the three below.arrow_forwardWeigh the following observation: High titers of antibodies for EBVare found in a leukemia patient; a chronically tired, ill businessman; a healthy military recruit; and an AIDS patient. Comment on theprobable significance of antibodies to EBV in human serum.arrow_forwardSelect all of the following that are functions performed by different antibodies. ( select all the correct answers) Group of answer choices a) Attracting natural killer cells to destroy an infected cell. b) Blocking the ability of a pathogen to bind to a host cell c) Lysing a pathogen cell wall or lipid bilayer. d) Marking a pathogen so that innate immune cells destroy the pathogen. e) Helping complement proteins bind to a pathogen.arrow_forward
- Match the antibody in Column A with its description or function in Column B. There may be more than one answer for each antibody.arrow_forwardCreate a concept map that describes antibodies using the following terms: Antibodies Agglutination Antibody-dependent cell-mediated cytotoxicity (ADDC) Antigens Antigen-stimulated B cells Complement activation IgA IgD IgE IgG IgM Inflammation Neutralization Phagocytosis Plasma cells Secreted immunoglobulinsarrow_forwardDescribe the reason that it is useful that antibodies have two antigen binding arms.arrow_forward
- Which of the following are elements of the structure of antibodies? Select all that apply. The antigen-binding sites of each antibody can bind to multiple antigen types. Four polypeptide chains are joined in a Y-shaped configuration. Each antibody has three binding sites for antigens. The antigen-binding sites are unique to each antibody.arrow_forwardWhich of the following binds to the Fc portion of the antibody? A. C1q B. C2a C. C1r D. C1s E. C2barrow_forwardWarm autoimmune hemolytic anemia, WAIHA, frequently have antibody specificity of: Question 6 options: A) anti-P B) anti-I C) anti-i D) anti-earrow_forward
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