To explain: The function of leptin and benefits of an adipose-derived signaling molecule to an animal.
Introduction: Different kinds of hormones contribute towards the energy balance by having an additional effect on the appetite of an individual. The hormone leptin was first characterized in 1994 in rodents. Presently, this hormone is found in all classes of vertebrates.
To explain: The function of appetite in an animals
Introduction: Different kinds of hormones contribute towards the energy balance by having an additional effect on the appetite of an individual. Leptin acts on the hypothalamus and inhibits the appetite of an individual. Presently, this hormone is found in all classes of vertebrates.
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Chapter 50 Solutions
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- Glucagon facilitates the adaptation of our body to fasting. Which enzymes of glucides (carbohydrates) metabolism are regulated, directly or undirectly, in response to the secretion of glucagon by pancreas?.arrow_forwardWhich might be a physiological phenotype associated with loss of function of GLUT1? inability of glucose to enter the intestinal cells from the intestinal lumen and high glucose excreted accumulation of glucose in the intestinal epithelial cytoplasm loss of glucose transport into somatic tissues (such as neurons in the brain) low glucose levels in the bloodstreamarrow_forwardLipodystrophy is a condition in which an individual lacks adipose tissue. The muscles and liver from such individuals are insulin resistant, and both tissues accumulate large amounts of triacylglycer ols (hyperlipidemia). The administration of leptin partly ameliorates this condition. What does it indicate about the relation of adipose tissue to insulin action?arrow_forward
- How do the pathways for the synthesis and breakdown of glycogen differ in liver and muscle? How does this relate to the function of stored glycogen in the two tissues?arrow_forwardPancreatic β cells express a receptor for fatty acids. Fatty acid binding to the protein appears to stimulate insulin secretion. Does this phenomenon make metabolic sense?arrow_forwardKetone bodies that build up under starvation conditions act as hunger suppressants and mentaldepressants. Does this make sense or would it make more sense for them to act as a stimulant to goout and find food? Explain.arrow_forward
- Leptin inhibits eating and is secreted in amounts in direct proportion to body fat. Moreover, obese people have normal amounts of leptin and leptin receptor. Why, then, do people become obese?arrow_forwardWhat is the function of the hormone leptin? Why has its discovery proved important in the area of regulation of feeding?arrow_forwardGiven insulin's structure, where is its target likely located? Insulin's adverse side effects include headache, nau- sea, hunger, confusion and weakness. What can these symptoms be attributed to? Insulin has major effects on muscle and adipose tissue. It increases the rate of glucose transport across the cell membrane, decreases the rate of lipolysis, and increases uptake of triglycerides and some amino acids from the blood. In doing so, what metabolic processes does it favor? Carbohydrates: Lipids: Proteins:arrow_forward
- What is caused (indirectly) by the binding of a glucagon molecule to its receptor on the surface of a liver cell? Phosphorylation of glycogen phosphatase, which results in it becoming less active. Dephosphorylation of glycogen synthase, which results in it becoming less active Phosphorylation of glycogen phosphorylase, which results in it becoming more active Dephosphorylation of phosphorylase kinase, which results in it becoming more active. Phosphorylation of glycogen synthase, which results in it becoming more activearrow_forwardFor an individual whose liver is regulated by glucagon binding, when energy is needed - what is the major carbon source used to produce acetyl CoA? Fatty acids Glucose Glyoxylate Amino acidsarrow_forwardWhat accounts for the fact that liver phosphorylase is a glucose sensor, whereas muscle phosphorylase is not?arrow_forward
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