Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
6th Edition
ISBN: 9780815344322
Author: Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher: W. W. Norton & Company
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Chapter 6, Problem 6P
Summary Introduction

To determine:  The direction of movement of RNA polymerase along the template to generate supercoiled structures in reference to the given figure and whether supercoils would be generated if RNA polymerase were free to rotate about the DNA axis.

Introduction:

RNA polymerase enzyme transcribes DNA to RNA during gene expression. It binds to promoter and opens the DNA double helix. The unpaired short stretch of nucleotide region forms transcription bubble.  It moves along the DNA for the polymerization of an RNA transcript. As it moves along template DNA, it causes superhelical tension such as loop or coil formation in the double helical DNA.

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