Concept explainers
(a)
Interpretation:
Among the given curves, the curve that represents the given perturbation is to be identified.
Concept introduction:
Proteins are the
(b)
Interpretation:
Among the given curves, the curve that represents the given perturbation is to be identified.
Concept introduction:
Proteins are the biomolecules which are composed of the long chain of amino acid residues. The protein which contains oxygen and is present in the red blood cells in the body is known as hemoglobin. It contains iron as well.
(c)
Interpretation:
Among the given curves, the curve that represents the given perturbation is to be identified.
Concept introduction:
Proteins are the biomolecules which are composed of the long chain of amino acid residues. The protein which contains oxygen and is present in the red blood cells in the body is known as hemoglobin. It contains iron as well.
(d)
Interpretation:
Among the given curves, the curve that represents the given perturbation is to be identified.
Concept introduction:
Proteins are the biomolecules which are composed of the long chain of amino acid residues. The protein which contains oxygen and is present in the red blood cells in the body is known as hemoglobin. It contains iron as well.
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BIOCHEMISTRY-ACHIEVE (1 TERM)
- Below is the oxygen saturation curve for myoglobin and hemoglobin at a pH of 7. The p50 for myoglobin is indicated by the dashed lines on the graph. Mb and Hb O2 saturation: pH 7 10 0.8 Myoglobin 0.6 P50 = 0.2 0.4 Hemoglobin 0.2 - 0.0 pO2 [kPa] Which of these molecules (Mb/Hb/neither or both) has cooperativity? [ Select ] What would you expect to happen to the p50 of myoglobin if the pH were decreased to a pH of 4? [ Select ] Fraction saturationarrow_forward. Carbonic anhydrase of erythrocytes (M, 30,000) has one of the highest turnover numbers known. It catalyzes the reversible hydration of CO₂. H₂O + CO₂ H₂CO3 This is an important process in the transport of CO₂ from the tissues to the lungs. If 3 µg of pure carbonic anhydrase catalyzes the hydration of 0.10 g of CO₂ in 1 min at 37 °C at Vmax, what is the turnover number (kcat) of carbonic anhydrase? Keat = 3.79 ×10-¹4 Incorrect I minarrow_forwardd) Determine which statements apply to hemoglobin, myoglobin, or neither (you can write in the corresponding numbers for each statement, as appropriate) Hemoglobin Myoglobin Neither 1. Oxygen binds irreversibly to this molecule.2. This molecule has greater affinity for oxygen.3. The oxygen dissociation curve is sigmoidal in shape.4. Carbon monoxide binds at an allosteric site, lowering oxygen binding affinity.5. The binding pattern for this molecule is considered cooperative.6. This molecule delivers oxygen more efficiently to tissues.7. As oxygen binds to this molecule, the shape of the molecule changes, enhancing further oxygen binding.8. The oxygen dissociation curve is hyperbolic in shape.arrow_forward
- Give detailed Solution with explanation (no need Handwrittenarrow_forwardBe able to describe the hemoglobin binding curve and why it is S shaped. Why is the shape important for loading and off-loading Oxygen? What is subunit cooperativity?arrow_forward. Oxygen binding by the hemocyanin of the shrimp Callianassa has been measured. Using the following data, prepare a Hill plot and determine (a) Pso, (b) h (the Hill coefficient), and (c) the minimum number of oxygen binding sites on the protein molecule. Poz (mm Hg) Yoz Po, (mm Hg) Yo2 1.1 0.003 136.7 0.557 7.7 0.019 166.8 0.673 10.7 0.035 203.2 0.734 31.7 0.084 262.2 0.794 71.9 0.190 327.0 0.834 100.5 0.329 452.0 0.875 123.3 0.487 736.7 0.913arrow_forward
- Brown induration of the lungs H&E staining, Perls reaction Mark the corresponding elements in the picture: A - H&E staining B - Perls reaction 1 - intraalveolar hemosiderin 2 - interstitial hemosiderin 3- alveolar lumen 4 - thickened, sclerosed alveolar walls Description: Perls's reaction isarrow_forwardBelow is the reaction catalyzed by carbonic anhydrase. Please answer the following questions. CO₂ + H₂O → H+ + HCO3* a. The forward reaction is favored in the lungs b. When protons decrease the pH [Select] [Select] c. CO₂ acts directly as a [Select] hemoglobin by reacting to form carbonic Answer 1: lungs Answer 2: decreases Answer 3: HbR Answer 4: negative heterotrophic state is favored Answer 5: and the allosteric effector of reacting to generate protons another allosteric effector that stabilizes the T statearrow_forwardcalculate the actual free energy of hydrolysis of ATP, delta Gp in the erythrocytes of a new species. The standard free-energy of hydrolysis of ATP is also -30.5kJ/mol in this species, but the concentrations in this specie's erythrocytes are 0.00775 mM ATP, 0.00027 mM ADP and 0.00418 mM Pi. Assume the pH is 7.0 and the body temperature of this species is 43.0oC. Calculate your answer as kJ/mol to two decimal places.arrow_forward
- O, saturation curve is shown beloww for hemoglobin at various pHs. Detail this Bohr effect from the molecular perspective. Be sure to include discussion of what causes this (i.e. specific amino acids), why the curves are right shifted with decreasing pH, and why this is logical in delivery of 02 to areas of higher demand. 100 Myoglobin 80- pH 7.6 60 pH 7.4 pll 7.2 40- pH 7.0 pH 6.8 20- Venous 0- 0. 20 10 60 80 Percent saturationarrow_forwarddiscuss the mechanism of the bohr effect that occurs during the interactions of Hb with oxygen under physiological conditions in the lungs and tissues. make use of relavant graphs and diagrams to explain your answer.arrow_forwardLabel the following equation. The parentheses represent the choices for each label (A-D). A. (Water, glucose, Carbon dioxide, Oxygen). B. (Water, glucose, Carbon dioxide, Oxygen) C. (Water, glucose, Carbon dioxide, Oxygen) D. (Water, glucose, Carbon dioxide, Oxygen)arrow_forward
- Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning