From the above mentioned table which patient have frameshift mutation. Concept introduction: A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

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Answer 1

Question

Chapter 7, Problem 18WIO

(a)

Summary Introduction

To determine:

From the above mentioned table which patient have frameshift mutation.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

(b)

Summary Introduction

To determine:

From the above mentioned table how many amino acids are missing from patient E.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

(c)

Summary Introduction

To determine:

Which patient will produce a shortened protein.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

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In a disorder called gyrate atrophy, cells in the retina begin to degenerate in late adolescence, causing night blindness that progresses to total blindness. The cause is a mutation in the gene that encodes an enzyme, ornithine aminotransferase (OAT). Researchers sequenced the OAT gene for 5 patients with the following results: Patient A: A change in codon 209 of UAU to UAA Patient B: A change in codon 299 of UAC to UAG Patient C: A change in codon 426 of CGA to UGA Patient D: A two-nucleotide deletion at codons 64 and 65 that results in a UGA codon at position 79. Patient E: Exon 6, including 1071 nucleotides is entirely deleted. Which patient(s) have a frameshift mutation? How many amino acids is patient E missing? Which patient(s) will produce a shortened protein?

Based on the following wild type sequence, indicate if each of the mutations should be classified as : insertion, deletion, missense, nonsense, silent (Use the provided Genetic Code table). Wild Type: GUC GCC GAC GAG AGG Mutant 1: GUC GCC AGA CGA GAG G Mutant 2: GUC GCC ACG AGA GG Mutant 3: GUC GCC AAC GAG AGG Mutant 4: GUA GCC GAC GAG AGG Mutant 5: GUC GCC GAC UAG AGG

A small section of a gene for a protein has the following nucleotide sequence: GCT CTA GCT ATC TGA Which of the following mutations would cuase a silent mutation in the sequence shown above? a. Replacement of second adenine base with thymine base b. Replacement of first thymine base with adenine base c. Replacement of second guanine base with cytosine base d. Replacement of first cytosine base with guanine base

Answer 2

Question

Chapter 7, Problem 18WIO

(a)

Summary Introduction

To determine:

From the above mentioned table which patient have frameshift mutation.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

(b)

Summary Introduction

To determine:

From the above mentioned table how many amino acids are missing from patient E.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

(c)

Summary Introduction

To determine:

Which patient will produce a shortened protein.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

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Answer 3

Question

Chapter 7, Problem 18WIO

(a)

Summary Introduction

To determine:

From the above mentioned table which patient have frameshift mutation.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

(b)

Summary Introduction

To determine:

From the above mentioned table how many amino acids are missing from patient E.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

(c)

Summary Introduction

To determine:

Which patient will produce a shortened protein.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

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Answer 4

Question

Chapter 7, Problem 18WIO

(a)

Summary Introduction

To determine:

From the above mentioned table which patient have frameshift mutation.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

(b)

Summary Introduction

To determine:

From the above mentioned table how many amino acids are missing from patient E.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

(c)

Summary Introduction

To determine:

Which patient will produce a shortened protein.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

Expert Solution & Answer

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Answer 5

Chapter 7, Problem 18WIO

(a)

Summary Introduction

To determine:

From the above mentioned table which patient have frameshift mutation.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

(b)

Summary Introduction

To determine:

From the above mentioned table how many amino acids are missing from patient E.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

(c)

Summary Introduction

To determine:

Which patient will produce a shortened protein.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

Answer 6

Chapter 7, Problem 18WIO

(a)

Summary Introduction

To determine:

From the above mentioned table which patient have frameshift mutation.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

Answer 7

Chapter 7, Problem 18WIO

(a)

Summary Introduction

To determine:

From the above mentioned table which patient have frameshift mutation.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

Answer 8

(b)

Summary Introduction

To determine:

From the above mentioned table how many amino acids are missing from patient E.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

Answer 9

(b)

Summary Introduction

To determine:

From the above mentioned table how many amino acids are missing from patient E.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

Answer 10

(c)

Summary Introduction

To determine:

Which patient will produce a shortened protein.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

Answer 11

(c)

Summary Introduction

To determine:

Which patient will produce a shortened protein.

Concept introduction:

A mutation is biological process which is defined as the permanent alteration in the nucleotide sequence of DNA. Mutation is unpredictable change that alters the protein function by changing shape of amino acid. It occurs naturally within the cell or by certain environmental factors such as ionizing and non-ionizing radiation.

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 7.1 - How did Griffiths research, coupled with the work...Ch. 7.1 - How did the Hershey-Chase blender experiments...Ch. 7.2 - What are the components of DNA and its...Ch. 7.2 - What evidence enabled Watson and Crick to decipher...Ch. 7.2 - Prob. 3MC Ch. 7.3 - What is the relationship between a gene and a...Ch. 7.3 - Prob. 2MC Ch. 7.3 - What are the three types of RNA, and how does each...Ch. 7.4 - What happens during each stage of transcription?Ch. 7.4 - Where in the cell does transcription occur?

Solution Summary: The author explains that a mutation is biological process that alters the nucleotide sequence of DNA.

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