Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 7, Problem 20P
Interpretation Introduction

Interpretation:

The list of all the modulators of oxygen binding by hemoglobin discussed in the given chapter is to be stated. The way by which the given modulators enhance the function of hemoglobin under physiological conditions is to be stated. Whether any of the modulator of hemoglobin also functions similarly in myoglobin or not is to be stated. The reason corresponding to the correct choice is to be stated.

Concept introduction:

Proteins are the biomolecules which are composed of the long chain of amino acid residues. The protein which contains oxygen and is present in the red blood cells in the body is known as hemoglobin. It contains iron as well. The protein that is an oxygen and iron containing protein present in the muscle tissue of mammals is known as myoglobin.

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After spending a day or more at high altitude (with an oxygen partial pressure of 75 torr), the concentration of 2,3- bisphosphoglycerate (2,3-BPG) in red blood cells increases. What effect would an increased concentration of 2,3-BPG have on the oxygen-binding curve for hemoglobin? Why would this adaptation be beneficial for functioning well at high altitude?
What is the role of 2, 3-Bisphosphoglycerate (2,3-BPG) in the function of haemoglobin as an oxygen carrier molecule? Explain the binding mechanism and effect of 2,3-BPG leading to the reduced oxygen binding affinity for haemoglobin and transitions in the T (deoxygenated) and R (oxygenated) states of haemoglobin.
Which of the following statements about the oxygen-binding curves is FALSE?
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