Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 7, Problem 9P
Interpretation Introduction
Interpretation:
The effect of the increased concentration of
Concept introduction:
The protein which contains oxygen and is present in the red blood cells in the body is known as hemoglobin. It contains iron as well.
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- Question- Some of the reactions of NO in the blood do not cause problems at low concentrations but can upset the normal reactions of hemoglobin if there is a large concentration of NO. The same reactions can cause trouble if a synthetic blood substitute contains a molecule similar to hemoglobin but does not contain all the other enzymes normally contained in red blood cells. Explain what this problem is and how it arises.arrow_forwardComparison of Fetal and Maternal Hemoglobins.Studies of oxygen transport in pregnant mammals show that the O2-saturation curves of fetal and maternal blood are markedly different when measured under the same conditions. Fetal erythrocytes contain a structural variant of hemoglobin, HbF, consisting oftwo a and two g subunits (α2γ2), whereas maternal erythrocytes contain HbA (α2β2). a)Which hemoglobin has a higher affinity for oxygen under physiological conditions, HbA or HbF? Explain. b)What is the physiological significance of the different O2 affinities? c)When all the BPG is carefully removed from samples of HbA and HbF, the measured O2-saturation curves (and consequently the O2affinities) are displaced to the left. However, HbA now has a greater affinity for oxygen than does HbF. When BPG is reintroduced, the O2-saturation curves return to normal, as shown in the graph. What is the effect of BPG on the O2affinity of hemoglobin? How can the above information be used…arrow_forwardOxygen-hemoglobin curve dissociation curve: Which various factors can determine the amount of saturation? why is this curve so steep? how ph and temperature affect it? how does the binding of oxygen molecules in bohr and haldane effect affect the 3d shape of hemoglobin and how does that have to do with the curve?arrow_forward
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