Concept explainers
Interpretation:
The reason behind the less dangerous effect of taking large quantities of valium than taking large quantities of phenobarbital.
Concept introduction:
A target site is the site to which the target molecule binds. The target molecule can be a hormone or a neurotransmitter. The target molecule discussed here is the GABA (gamma-aminobutyric acid), which is an inhibitory neurotransmitter.
Phenobarbital and valium are depressants of the central nervous system. Phenobarbital is an orthosteric drug that binds to the target site of the receptor. Valium is a derivative of the chemical compound called benzodiazepine, and is an allosteric drug. An allosteric drug binds at the allosteric site of the receptor, which is other than the active site, whereas phenobarbital binds to the target site.
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Chapter 7 Solutions
Biochemistry
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- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage Learning