Concept explainers
a.
To identify: a. The deletion of exon 3; b. The deletion of six consecutive
Concept introduction:
The inherited cases resulted from the mutation in a gene encodes the protein parkin. The protein parkin includes 12 exons. This is a type of disease in which only 2% of cases are inherited. The protein formation is affected by the deletion and insertion of introns and exons.
b.
To identify: Deletion of six consecutive nucleotides in exon 1 in the parkin gene would result in a smaller protein, a larger protein or no change in the size of the protein.
c.
To identify: Duplication of exon 5 in the parkin gene would result in a smaller protein, a larger protein or no change in the size of the protein.
d.
To identify: Disruption of splice site between exon 8 and introns 8 in the parkin gene would result in a smaller protein, a larger protein or no change in the size of the protein.
e.
To identify: Deletion of introns 2 in the parkin gene would result in a smaller protein, a larger protein or no change in the size of the protein
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