Statistics For Business And Economics Plus Mystatlab With Pearson Etext -- Access Card Package (13th Edition)
Statistics For Business And Economics Plus Mystatlab With Pearson Etext -- Access Card Package (13th Edition)
13th Edition
ISBN: 9780134648361
Author: James T. McClave, P. George Benson, Terry Sincich
Publisher: PEARSON
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Chapter 7.4, Problem 7.34ACB

Stability of compounds in new drugs. Refer to the ACS Medicinal Chemistry Letters (Vol. 1. 2010) study of the metabolic stability of drugs, Exercise 2.221 (p. 59). Recall that two important values computed from the testing phase are the fraction of compound unbound to plasma (fup) and the fraction of compound unbound to microsomes (fumic). A key formula for assessing stability assumes that the fup/fumic ratio is 1:1. Pharmacologists at Pfizer Global Research and Development tested 416 drugs and reported the fup/fumic ratio for each. These data are saved in the FUP file, and summary statistics are provided in the accompanying Minitab printout. Suppose the pharmacologists want to determine if the true mean ratio, μ, differs from 1.

  1. a. Specify the null and alternative hypotheses for this test.
  2. b. Descriptive statistics for the sample ratios are provided in the Minitab printout on page 386. Note that the sample mean. x ¯ = .327 is less than 1. Consequently, a pharmacologist wants to reject the null hypothesis. What are the problems with using such a decision rule?
  3. c. Locate values of the test statistic and corresponding p-value on the printout.
  4. d. Select a value of, the probability of a Type I error. Interpret this value in the words of the problem.
  5. e. Give the appropriate conclusion. based on the results of parts c and d.
  6. f. What conditions must be satisfied for the test results to be valid?

Chapter 7.4, Problem 7.34ACB, Stability of compounds in new drugs. Refer to the ACS Medicinal Chemistry Letters (Vol. 1. 2010)

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Chapter 7 Solutions

Statistics For Business And Economics Plus Mystatlab With Pearson Etext -- Access Card Package (13th Edition)

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For each of the...Ch. 7.3 - If a hypothesis test were conducted using = .05,...Ch. 7.3 - For each and observed significance level...Ch. 7.3 - In a test of the hypothesis H0: = 50 versus H0: ...Ch. 7.3 - In a test of H0: = 100 against Ha: 100 the...Ch. 7.3 - In a test of the hypothesis H0: = 10 versus Ha: ...Ch. 7.3 - In a test of H0: = 100 against Ha: 100, the...Ch. 7.3 - In a test of H0: = 75 performed using the...Ch. 7.3 - An analyst tested the null hypothesis that 20...Ch. 7.4 - Consider the test H0: = 70 versus Ha: 70 using...Ch. 7.4 - Suppose you are interested in conducting the...Ch. 7.4 - A random sample of 100 observations from a...Ch. 7.4 - A random sample of 64 observations produced the...Ch. 7.4 - Use the applet Hypotheses Test for a Mean to...Ch. 7.4 - Use the applet Hypotheses Test for a Mean to...Ch. 7.4 - Use the applet Hypotheses Test for a Mean to...Ch. 7.4 - Corporate sustainability of CPA firms. Refer to...Ch. 7.4 - Packaging of a childrens health food. 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List three factors that will increase the power...Ch. 7.8 - Prob. 7.97LMCh. 7.8 - Prob. 7.98LMCh. 7.8 - Prob. 7.99LMCh. 7.8 - Refer to Exercise 7.99. a. Find for each of the...Ch. 7.8 - Prob. 7.101LMCh. 7.8 - Prob. 7.102ACICh. 7.8 - Prob. 7.103ACICh. 7.8 - Prob. 7.104ACICh. 7.8 - Prob. 7.105ACICh. 7.8 - Prob. 7.106ACICh. 7.8 - Prob. 7.107ACICh. 7 - Specify the differences between a large-sample and...Ch. 7 - Complete the following statement; The smaller the...Ch. 7 - Which of the elements of a test of hypothesis can...Ch. 7 - If you select a very small value for when...Ch. 7 - If the rejection of the null hypothesis of a...Ch. 7 - A random sample of 20 observations selected from a...Ch. 7 - A random sample of 175 measurements possessed a...Ch. 7 - A random sample of n = 200 observations from a...Ch. 7 - A t-test is conducted for the null hypothesis H0 :...Ch. 7 - A random sample of 41 observations from a normal...Ch. 7 - Effectiveness of online courses. 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