Chapter 9, Problem 3IC

Summary Introduction

To answer:

How $pKa$ and $pH$ affects drug delivery.

Introduction:

pKa is a measure of acid strength and it depends on the identity and chemical properties of the acid whereas $pH$ is a measure of H⁺ ions in a solution. For acids, the lesser the $pKa$, the more acidic the substance is, because more easily a proton is lost, thus the lower the $pH$.