Concept explainers
To determine:
An anesthetic drug between mepivacaine and bupivacaine which will have more of the uncharged form available at physiological
Introduction:
Mepivacaine and bupivacaine are local anesthetic drugs of the amino ester group used in epidural blocks. They contain an
The equilibrium constant
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GENERAL, ORGANIC, AND BIOLOGICAL CHEMIS
- All amino acids have at least two functional groups with acidic or basic properties. In alanine, the carboxylic acid group has Ka = 4.5 103 and the amino group has Kb = 7.4 105. Three ions of alanine are possible when alanine is dissolved in water. Which of these ions would predominate in a solution with [H+] = 1.0 M? In a solution with [OH] = 1.0 M?arrow_forwardAscorbic acid (vitamin C, C6H8O6) is a diprotic acid (Ka1 = 6.8 105 and Ka2 = 2.7 1012). What is the pH of a solution that contains 5.0 mg of acid per millilitre of solution? Ascorbic acidarrow_forward0.270 M monoprotic weak acid solution has a pH of 2.50. What is the pKa of this acid? a. 4.43 b. 1.93 c. 5.57 d. 9.57arrow_forward
- Benozic acid (C6H5COOH) has a pKa of 4.20. What is the ratio of the acid to its conjugate acid at a pH of 2.20 and what is the formula of the conjugate acid?arrow_forwardCalculate the pKa of the weak acid HA, given that a solution that is 0.357 in HA and 1.24 in A- has pH = 5.32.Provide your answer rounded to 2 decimal digits.arrow_forwardThe weak acid HQ has a pKₐ of 4.89.(a) Calculate the [H3O⁺] of 3.5X10⁻² M HQ.(b) Calculate the [OH⁻] of 0.65 M HQ.arrow_forward
- A 0.119 M solution of Covidenol, a weak acid, has a measured pH of 3.45. Determine the pKa of Covidenol.arrow_forwardIf H2O has a pKa value of 15.7 and HF has a pKa value of 3.2, which is a stronger base, HO- or F-? Explain.arrow_forwardWithout reference to a pKa table, decide which compound in each pair is the stronger acid.arrow_forward
- Arsenic acid, a triprotic acid, has 3 pKa values (2.24, 6.96, and 11.50). What is the predominate form of arsenic acid at a pH of 4.00? H3A H2A– A3– The predominate form of arsenic acid cannot be determined from the given information. HA2–arrow_forward(b) Calculate the pH of 0.0005 mol dm-3 ethanoic acid when its pKa = 4.75 and explain the assumptions made in the calculations CH3COOH(aq) CH3COO-(aq) + H+(aq) Ka = pH =arrow_forwardShow how you calculated the pka of the two acids A) phosphoric acid ph= 2.63 B) sulphurous acid ph= 2.30arrow_forward
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