EBK BIOLOGY
4th Edition
ISBN: 8220102797376
Author: BROOKER
Publisher: YUZU
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Chapter 9.3, Problem 2CC
Summary Introduction
To explain: Whether phosphorylation activates or inhibits enzyme function.
Introduction: The catalytic subunit of protein kinase A phosphorylates various cellular proteins such as structural proteins, transcription factor, enzymes. The phosphorylation process influences the function and structure of the enzyme.
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Q8.3: Glucocorticoids are potent anti-inflammatory molecules that repress inflammation through transcriptional mechanisms. Beginning with inhalation of the asthma drug fluticasone, describe how this treatment reduces inflammation at the molecular level.
Docking and Membrane Fusion.
Q-8a. Choose from the terms below to Fill-in the Blanks.
[All terms are used. Some terms are used more than once]
Rab,
SNARE,
v- SNARE,
t-SNARE,
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a. Identification of a vesicle to be docked depends on a diverse family of monomeric GTPases called
proteins. First, a filamentous
protein on a target membrane binds to a
protein
on the surface of a vesicle. This interaction allows the vesicle to dock on its particular target membrane. A
on the vesicle then binds to a complementary_
on the target membrane.
Whereas
and
proteins provide the initial recognition between a vesicle and
its target membrane, complementary
appropriate target membranes. Together, the
proteins ensure that transport vesicles dock at their
proteins catalyze the final fusion of the two
membranes by squeezing out water making fusion more energetically favorable.
b. What does the acronym SNARE stand for?
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RTK: What would the following double mutations mean for the status of the signaling pathway, and the phosphorylation of MAPKK (MEK)?
1. Ligand is bound to the receptor; MAPK T120A mutation (T120 is normally phosphorylated by MAPKK)
a) Pathway ON (final output is achieved)
b) Pathway OFF (no final output)
c) Phosphorylation of MAPKK MEK
d) NO Phosphorylation of MAPKK MEK
2) Ligand is not bound to the receptor; MAPKKK T132E mutation (T132 is normally phosphorylated by Ras)
a) Pathway ON (final output is achieved)
b) Pathway OFF (no final output)
c) Phosphorylation of MAPKK MEK
d) NO Phosphorylation of MAPKK MEK
Chapter 9 Solutions
EBK BIOLOGY
Ch. 9.1 - Figure 9.1 Response of a yeast cell to glucose....Ch. 9.1 - Prob. 1BCCh. 9.1 - Which type of signal, paracrine or endocrine, is...Ch. 9.1 - Prob. 3CCCh. 9.2 - Prob. 1BCCh. 9.2 - Prob. 1CCCh. 9.2 - Prob. 2CCCh. 9.3 - Prob. 1BCCh. 9.3 - Prob. 1CCCh. 9.3 - Prob. 2CC
Ch. 9.3 - In the case of signaling pathways involving...Ch. 9.5 - Prob. 1EQCh. 9.5 - Prob. 2EQCh. 9.5 - Prob. 3EQCh. 9.5 - Prob. 1CCCh. 9 - Prob. 1TYCh. 9 - Prob. 2TYCh. 9 - Prob. 3TYCh. 9 - Prob. 4TYCh. 9 - Prob. 5TYCh. 9 - The relay protein Ras is part of the EGF pathway...Ch. 9 - Prob. 7TYCh. 9 - Prob. 8TYCh. 9 - Prob. 9TYCh. 9 - Prob. 10TYCh. 9 - Prob. 1CQCh. 9 - Conceptual Questions What are the three stages of...Ch. 9 - Prob. 3CQCh. 9 - Prob. 1COQCh. 9 - Prob. 2COQ
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