EP CONNECT ONLINE ACCESS FOR BIOLOGY
20th Edition
ISBN: 9781260494655
Author: Raven
Publisher: MCG COURSE
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Question
Chapter 9.4, Problem 4LO
Summary Introduction
To determine: The possible reasons for the mutation of Ras protein in human cancers.
Introduction: Ras is a GTP binding protein and acts as a link between receptor tyrosine kinase (RTK) and mitogen-activated protein (MAP) kinases. The protein is in an active state when bound to GTP and is in an inactive state when bound to GDP.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Do you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras
that lead to cancer? Please explain.
Describe the common signal transduction event that is perturbed by cancer-promoting mutations in the genes encoding RAS and NF-1. Why are mutations in RAS more commonly found in cancers than mutations in NF-1?
The chemical carcinogen dimethybenzialanthracene (DMBA) must be an extraordinarily specific mutagen since 90% of the skin tumors it causes have an A-to-Talteration at exactly the same site in the mutant Ras gene is true or false
Chapter 9 Solutions
EP CONNECT ONLINE ACCESS FOR BIOLOGY
Ch. 9.1 - Prob. 1LOCh. 9.1 - Prob. 2LOCh. 9.2 - Prob. 1LOCh. 9.3 - Prob. 1LOCh. 9.3 - Prob. 2LOCh. 9.4 - Prob. 1LOCh. 9.4 - Describe how information crosses the membrane in...Ch. 9.4 - Prob. 3LOCh. 9.4 - Prob. 4LOCh. 9.5 - Prob. 1LO
Ch. 9.5 - Prob. 2LOCh. 9 - Paracrine signaling is characterized by ligands...Ch. 9 - Signal transduction pathways a. are necessary for...Ch. 9 - The function of a ____is to add phosphates to...Ch. 9 - Which of the following receptor types is NOT a...Ch. 9 - How does the function of an intracellular receptor...Ch. 9 - Signaling through receptor tyrosine kinases often...Ch. 9 - Prob. 7UCh. 9 - Which of the following best describes the...Ch. 9 - Prob. 1ACh. 9 - The ion Ca2+ can act as a second messenger because...Ch. 9 - Different receptors can have the same effect on a...Ch. 9 - In comparing small G proteins like Ras and GPCR...Ch. 9 - Prob. 5ACh. 9 - The receptors for steroid hormones and peptide...Ch. 9 - Describe the common features found in all examples...Ch. 9 - The sheet of cells that form the gut epithelium...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- A mutation in the Ras protein renders Ras constitutively active (RasD). What is constitutive activation?arrow_forwardHow does constitutively active Ras promote cancer?arrow_forwardWhile a stem cell transplant from an unaffected donor is currently the only cure for DBA, genome-editing technologies may one day enable the correction of a mutation in a patient’s own bone marrow stem cells. However, what specific information would be needed, beyond a symptom-based diagnosis of DBA, in order to accomplish this?arrow_forward
- What are Ras protein and p53? How can mutations in the genes for these proteins contribute to cancer?arrow_forwardSome cancers are consistently associated with the deletion of a particularpart of a chromosome. Does the deleted region contain an oncogene or atumor-suppressor gene? Explain.arrow_forwardDescribe the mutational event that produces the MYC oncogene in Burkitt’s lymphoma. Why does the particular mechanism for generating oncogenic MYC result in a lymphoma rather than another type of cancer? Describe another mechanism for generating oncogenic MYC.arrow_forward
- The p53 protein was discovered through its association with SV40 T antigen and assumed initially to be an oncoprotein. a. What is the current consensus as the function of p53 and what evidence caused this change in view? b. How does the effect of mutation in the p53 gene differ from the effect of mutation in the RB gene what is the molecular basis for this difference ?arrow_forward''The chemical carcinogen dimethylbenz[a]anthra-cene (DMBA) must be an extraordinarily specific mutagensince 90% of the skin tumors it causes have an A-to-T alter-ation at exactly the same site in the mutant Ras gene.'' Is this statement true? Explain why or why not.arrow_forwardwhat are the rolls that the p53 gene and RAS protein take on when trying to stop a cancer cell from further replicating. Also, what would happen if a mutation were to occur in both genes?arrow_forward
- Mutational signatures of p53 are shown in this image (G.P. Pfeifer et al., Nature, 21(48), 2002) for the three types of cancer with the highest death rates in the United States: lung (~225,000 deaths in 2016), breast (246,000), and colorectal (381,000). These data can be obtained by sequencing the gene that encodes p53. Approximately 85 percent of lung cancers occur in smokers. Based on these data, calculate how many deaths due to lung cancer among nonsmokers were reported in 2016. How much does smoking increase the likelihood of death due to lung cancer?arrow_forwardThe p53 gene is a tumor-suppressor gene while Ras is a proto-oncogene. Mutation in either one can result in the transformation of a normal cell into a cancer cell. Explain the difference between the functions of the two proteins and how their mutation can lead to cancer development.arrow_forwardCancer-promoting mutations are likely to have different effects on the activity of proteins encoded byproto-oncogenes than they do on proteins encodedby tumor-suppressor genes. Explain.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSON
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Anatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
An Introduction to the Human Genome | HMX Genetics; Author: Harvard University;https://www.youtube.com/watch?v=jEJp7B6u_dY;License: Standard Youtube License