Biology: Life on Earth with Physiology (11th Edition)
Biology: Life on Earth with Physiology (11th Edition)
11th Edition
ISBN: 9780133923001
Author: Gerald Audesirk, Teresa Audesirk, Bruce E. Byers
Publisher: PEARSON
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Chapter 9.5, Problem 1CSC

Body, Heal Thyself

The precision of mitotic cell division is essential for repairing damaged tissues like those in Bartolo Colón’s pitching arm. Imagine what might happen if DNA synthesis during interphase did not copy all of the genes accurately, or if mitotic cell division sent random numbers and types of chromosomes into the daughter cells. Some of the daughter cells might not contain all the genes needed to form the cell types that are required to repair damaged tissues. Other daughter cells might have genetic changes that stimulate unrestrained cell division and cause cancer. In cancer cells, the cell cycle spins out of control, but under normal circumstances cell division is precisely regulated. How does the body usually control the cell cycle?

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Mitosis DrawingIn this assignment you will track and draw the chromosomes of a diploid organism through all the stages of mitosis. Make sure to draw the alleles for genes A and B on the chromatids in every stage. For mitosis, remember that many events are going on in the cell that are relevant besides just the movement of chromosomes, so please fill in the cell with pertinent structures such as centrioles and spindles.
In the tracking chromosomal DNA movement through mitosis experiment, how many chromosomes did each of your daughter cells contain? Why is it important for each daughter cell to contain information identical to the parent cell? How often do human skin cells divide? Why might that be? Compare this rate to how frequently human neurons divide. What do you notice?
In class, we talked about flow cytometry which allows scientists to determine what stage of the cell cycle cells are in by measuring their DNA content. Draw what the graph would look like for the mutant below at a 0-time point when there are 1000 cells total, with 5000 cells in G1, 350 cells in M and G2, and 150 cells in S phase. And then a graph of 1 hour later when the cells should have competed for mitosis:  → loss of function of cdc25

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Biology: Life on Earth with Physiology (11th Edition)

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The Cell Cycle and its Regulation; Author: Professor Dave Explains;https://www.youtube.com/watch?v=eqJqhA8HSJ0;License: Standard YouTube License, CC-BY
Cell Division - Mitosis and Meiosis - GCSE Biology (9-1); Author: Mr Exham Biology;https://www.youtube.com/watch?v=w7vp_uRA8kw;License: Standard YouTube License, CC-BY