Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Textbook Question
Chapter 10, Problem 2VCQ
Figure 10.13 Rb and other proteins that negatively regulate the cell cycle are sometimes called tumor suppressors. Why do you think the name tumor suppressor might be appropriate for these proteins?
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Students have asked these similar questions
Much remains unknown about the rapid, uncontrolled growth, or what causes a tumor to metastasize. Scientists do know that cancer cells come from normal healthy cells that have had some type of damage done to the genes that aid in the production of the regulatory proteins for the cell cycle. What causes this damage?
a
proto-oncogenes
b
mutations
c
enzymes
d
tumor suppressors
Which of the following is not a tumor suppressor gene?
a.RET
b.RB
c.BRCA1
d.BRCA2
Gas pedal that works normally and helps the cell to divide can be compare to what kind of gene ? Is it oncogene , proto - oncogene or tumor suppressor gene ? Explain your answer.
Chapter 10 Solutions
Biology 2e
Ch. 10 - Figure 10.6 Which of the following is the correct...Ch. 10 - Figure 10.13 Rb and other proteins that negatively...Ch. 10 - Figure 10.14 Human papillomavirus can cause...Ch. 10 - A diploid cell has ________ the number of...Ch. 10 - An organism s traits are determined by the...Ch. 10 - The first level of DNA organization in a...Ch. 10 - Identical copies of chromatin held together by...Ch. 10 - S. Chromosomes are duplicated during what stage of...Ch. 10 - Which of the following events does not occur...Ch. 10 - The mitotic spindles arise from which cell...
Ch. 10 - Attachment of the mitotic spindle fibers to the...Ch. 10 - Unpacking of chromosomes and the formation of a...Ch. 10 - Separation of the sister chromatids is a...Ch. 10 - The chromosomes become visible under a light...Ch. 10 - The fusing of Golgi vesicles at the metaplhase...Ch. 10 - At which of the cell-cycle checkpoints do external...Ch. 10 - What is the main prerequisite for clearance at the...Ch. 10 - If the M checkpoint is not cleared, what stage of...Ch. 10 - Which protein is a positive regulator that...Ch. 10 - Many of the negative regulator proteins of the...Ch. 10 - Which negative regulatory molecule can trigger...Ch. 10 - are changes to the order of nucleotides in a...Ch. 10 - A gene that codes for a positive cell-cycle...Ch. 10 - A mutated gene that codes for an altered version...Ch. 10 - Which molecule is a Cdk inhibitor that is...Ch. 10 - Which eukaryotic cell-cycle event is missing in...Ch. 10 - FtsZ proteins direct the formation of a...Ch. 10 - Compare and contrast a human somatic cell to a...Ch. 10 - What is the relationship between a genome,...Ch. 10 - Eukaryotic chromosomes are thousands of times...Ch. 10 - Briefly describe the events that occur in each...Ch. 10 - Chemotherapy drugs such as vincristine (derived...Ch. 10 - Describe the similarities and differences between...Ch. 10 - List some reasons why a cell that has just...Ch. 10 - What cell-cycle events will be affected in a cell...Ch. 10 - Describe the general conditions that must be met...Ch. 10 - Compare and contrast the roles of the positive...Ch. 10 - What steps are necessary for Cdk to become fully...Ch. 10 - Rb is a negative regulator that blocks the cell...Ch. 10 - Outline the steps that lead to a cell becoming...Ch. 10 - Explain the difference between a proto-oncogene...Ch. 10 - List the regulatory mechanisms that might be lost...Ch. 10 - ______ can trigger apoptosis if certain cell-cycle...Ch. 10 - Name the common components of eukaryotic cell...Ch. 10 - Describe how the duplicated bacterial chromosomes...
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- Another model, the random model, proposes that any cell in a malignant tumor has the potential to form a new tumor. Does the cancer stem cell hypothesis contradict this idea?arrow_forwardTumor suppressor genes _____. a. occur normally in cells b. promote metastasis c. are brought into cells by viruses d. only rarely affect the development of cancerarrow_forwardHow can errors in the cell cycle lead to cancer in humans?arrow_forward
- Answer each question with a paragraph; 3-5 sentences each. Explain the difference between a proto-oncogene and a tumor-suppressor gene. Explain the difference between prokaryotic and eukaryotic cell division. Explain the difference between positive regulation of the cell cycle and negative regulation of the cell cycle. Explain the difference between normal p53 and mutated p53. Find two differences and two similarities between binary fission and mitosis.arrow_forwardA tumor suppressor gene ___regulates the cell cycle; an example is _____. Select one: a. negatively, cyclin b. positively, retinoblastoma c. positively, p21 d. negatively, retinoblastoma e. positively, RASarrow_forwardWhich of the following statements correctly describes a characteristic of tumor-suppressor gene? a) they are frequently overexpressed in cancerous cells. b) they are cancer-causing genes introduced into cells by viruses. c) they encode proteins that help prevent uncontrolled cell growth. d) they often encode proteins that stimulate the cell cycle.arrow_forward
- Which of the following best describes a gene that codes for a tumor-suppressor protein? a. One that helps to prevent progression through the cell cycle. b. One that helps prevent apoptosis. c. One that codes for a DNA repair enzyme. d. One that supports part of a growth factor signaling pathway.arrow_forwardIn some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an oncogene or a tumor-suppressor gene? Explain your reasoningarrow_forwardWhich of these events do you think is likely to promote tumorigenesis in affected cells? Group of answer choices DNA methylation of the promoter region of a tumor suppressor gene Hypermethylation of transcription factors that antagonize Wntsignaling Open chromatin in the region of of DNA harboring an activating mutation of beta-catenin All of thesearrow_forward
- Oncologists (cancer doctors) frequently measure the mitotic index of tumor cells when they are removed via surgery or biopsy. What do you think is the value of finding out the mitotic index of these cells?arrow_forwardYou found a protein called X in colon cancer patients that is over-expressed and is associated with metastasis. This is funky because the same protein X is acts as a tumor suppressor in BC and is known as protein Y. How could this be true? Create an hypo and a way to test it.arrow_forwardWhich of the following is a trait that is detrimental to cancer cell progression? Drug Resistance Recognition by the immune system Angiogenesis (growth of new blood vessels) Deactivation of the tumor suppressor Rbarrow_forward
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