Pearson eText Genetic Analysis: An Integrated Approach -- Instant Access (Pearson+)
3rd Edition
ISBN: 9780135564172
Author: Mark Sanders, John Bowman
Publisher: PEARSON+
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Chapter A, Problem 6P
A
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What is Down's syndrome? Give its symptoms and cause. Why is it that
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Why is the chances of having a child with down's syndrome increases if the age of mother exceed forty year?
Children with this condition has the following features: wide or web-like neck; low-set ears; broad chest with widely spaced nipples; high, narrow roof of the mouth (palate); arms that turn outward at the elbows; fingernails and toenails that are narrow and turned upward; swelling of the hands and feet, especially at birth; slightly smaller than average height at birth; slowed growth; and cardiac defects.
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Chapter A Solutions
Pearson eText Genetic Analysis: An Integrated Approach -- Instant Access (Pearson+)
Ch. A - Match each statement (a-e) with the best answer...Ch. A - Go online to the Mendelian Index of Man (OMIM)...Ch. A - A.3 A couple comes into your genetic counseling...Ch. A - A man, J.B., has a sister with autosomal recessive...Ch. A - A.5 A woman, S.R., had a maternal grandfather with...Ch. A - A.6 A -year-old woman whose father had Huntington...
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- The father of five children begins to show symptoms of huntington disease. what is the probability that same, the man's second oldest son (11-2),, will suffer from the disease if he lives a normal life span? Sam's mother and her ancestors do not have the diseas. Sam's father was adopted, so we do not know his biological family history for hunutington disease. Explore all possible outcome for sam and explain your reasoningarrow_forwardMuscular dystrophy is a group of disorders that involve muscle m weakness and loss of muscle tissue that get worse overtime. A homozygous normal female has children with a male who has muscular dystrophy. What is the probability that they will have a child who is both MALE and HAS MUSCULAR DYSTROPHY?arrow_forwardNeither Tim nor Rhoda has Duchenne muscular dystrophy, but their firstborn son does. What is the probabilitythat a second child will have the disease? What is theprobability if the second child is a boy? A girl?arrow_forward
- Using the two equations, p + q = 1 and p2 + 2pq + q2 = 1, answer the following question A Hispanic-American couple wants to know their risk for having a child with cystic fibrosis. One parent has no family history of disease, but the other parent has a sibling with cystic fibrosis. Calculate the conditional probability that the couple has a child with cystic fibrosis.arrow_forwardThe father of three sons and two daughters begins to show symptoms of Huntington's disease. What is the probability that Sam, the man’s second oldest son (II-2), will suffer from the disease if he lives a normal life span? Sam’s mother and her ancestors do not have the disease. Sam's father was adopted, so we do not know his biological family history for Huntington disease. Explore all possible outcomes for Sam and explain your reasoning. What about the risk to Sam's sisters? Would that be the same or not?arrow_forwardWhat would be the phenotypes for each of the following genotypes for Huntington’s Disease? a. Hh = b. hh =arrow_forward
- Please answer with reason: 1) The nurse is explaining the inheritance of Huntington disease (autosomal dominant) to a newly diagnosed patient whose partner does not have the gene mutation. Which statement should the nurse make regarding family planning? a. There is a 100% chance with each pregnancy that the child will inherit the gene for Huntington disease. b. There is a 50% chance with each pregnancy that the child will inherit the gene for Huntington disease c. There is a 25% chance with each pregnancy that the child will inherit the gene for Huntington disease d. There is a 0% chance with each pregnancy that the child will inherit the gene for Huntington disease.arrow_forwardQ1: Which of the children in this Punnett square represents Zoe? What is her genotype? Q2: If Zoe’s parents had another child, what is the probability that the child would have cystic fibrosis? That the child would be a CF carrier? Q3: If Zoe is able to have a child of her own someday, and the other parent is not a carrier of cystic fibrosis (he would likely be tested before they chose to have children), what is the probability that the child would have cystic fibrosis? That the child would be a carrier?arrow_forwardBecause Elsa has received a confirmed diagnosis of beta-thalassemia major, which of the following statements is true about her parents? Only her mother carried the gene that caused her blood disorder. Only her father carried the gene that caused her blood disorder. If her parents have another child naturally, there is a 100% chance that the second child will be diagnosed with beta-thalassemia major. If her parents have another child naturally, there is a 25% chance that the second child will be diagnosed with beta-thalassemia major.arrow_forward
- Suppose a couple brought to you their 8-year old boy with progressive muscle weakness, and difficulty in motor skills resulting to awkward manner of walking and running . The boy’s 15-year old sister and11-year old brother appear to be unaffected. They have a normal father and a normal pregnant mother. The mother had a brother who died at 26 yrs. of age with similar findings that seemed to worsen with age. The mother also has a sister with the same findings but it only manifested during her 28 th year. Her sister, who married an unaffected man, has two affected sons and a normal daughter.You suspect a diagnosis of Duchenne Muscular Dystrophy (DMD).arrow_forwardSuppose a couple brought to you their 8-year old boy with progressive muscle weakness, and difficulty in motor skills resulting to awkward manner of walking and running . The boy’s 15-year old sister and11-year old brother appear to be unaffected. They have a normal father and a normal pregnant mother. The mother had a brother who died at 26 yrs. of age with similar findings that seemed to worsen with age. The mother also has a sister with the same findings but it only manifested during her 28 th year. Her sister, who married an unaffected man, has two affected sons and a normal daughter.You suspect a diagnosis of Duchenne Muscular Dystrophy (DMD). a. Draw the pedigree of this family. Follow protocols in making a pedigree. Provide the genotype of all individuals in the pedigree. Please provide also the gene notation. b. What is most likely the pattern of inheritance for this condition? c. Justify your answer in letter (b).d. What is the risk (probability) that the fetus is affected?…arrow_forwardWhat are newest advances in early diagnosis and confirmation of Huntington disease? Explain the difference in inheritance pattern and the frequency to have affected progeny in the case of these three inherited diseases: Huntington, Cystic fibrosis and Duchenne muscular dystrophy. What therapies can be used or recommended for patients experiencing any of these inherited diseases?arrow_forward
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