Single domain antibody

Padmina Shrestha BIO 222 Prof. Bill Thomas 11/03/2014 Kinetochore-microtubule interaction and the role of Aurora kinase B All living organisms are a result of multiple rounds of cell division; new cells can only be formed from pre-existing cells. For the duplication of cells, genetic materials as well as other organelles in a cell have to duplicate in order to pass down the information about how to organize the cells (Alberts, et al., 2008). During S phase of the cell cycle, chromosomes as well

Cancer is the second leading cause of death with 14 million new cases and 8.2 million cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies, neoplastic diseases are still a major therapeutic challenge notably because of intra- and inter-malignant tumor heterogeneity and adaptation/escape of malignant cells to/from treatment. New targeted therapies need to be developed to improve our medical arsenal and counter-act cancer progression. Human kallikrein-related peptidases

Bacillus Anthracis and Biological Warfare Bacillus anthracis is a rod-shaped, nonmotile, aerobic, gram-positive bacterium that can be transmitted from herbivoric animals to humans (Figure 1). Before an animal’s death, its orifices exude blood containing huge quantities of the bacterium. Anthrax forms extremely resilient spores upon exposure to atmospheric conditions. Because of this spore-producing ability, even after the animal host dies the germs can sporulate again, persisting in the soil

The virus known as Measles There are many viruses today that at one time were a deadly disease, however because of advances in technology and vaccinations, we no longer give them a second thought. Prior to the discovery of a vaccination, the United States reported a total of over 50,000 cases of measles outbreaks each year with 450-500 cases resulting in death. (NCIRD) Since the disbursement of an effective vaccination, the measles has been almost eradicated in the United States; however it is

The prostate is a walnut sized shaped gland surrounding the top of the urethra whose growth and function is controlled by hormones such-as testosterone. A normal prostate in adult men has a mean weight of about 11g. The function of the prostate is to produce a majority of seminal fluid (Marker et al. 2003). Prostate cancer (PCa) is the commonest malignancy tumour in men and is second in cancer related death after lung cancer. PCa is mainly adenocarcinomas originating from the cortex of the gland

as under: • Physical agents like heat, cold, radiation, mechanical trauma. • Chemical agents like organic and inorganic poisons. • Infective agents like bacteria, viruses and their toxins. • Immunological agents like cell mediated and antigen-antibody reactions. 1.1.2. Signs of Inflammation Following are the cardinal signs of inflammation: • Redness • Swelling • Heat • Pain • Loss of function 1.1.3. Sources of Chemical Mediators The most common sources of chemical mediators are as

molecule: (A) is slightly negative at one end and slightly positive at the other end (B) has an extra electron, giving it a positive charge (C) has an extra electron giving it a negative charge (D) has covalent bonds (E) is comprised of a single atom 17. Proteins are an essential component of a healthy diet for humans (and other animals). Their most common purpose is to serve as: (A) raw material for growth (B) fuel for running the body (C) organic precursors for enzyme construction

Title: Cloning of Enhancer of Zeste Homolog 2 in forward orientation into Escherichia Coli using histidine-tagged pbluescript II KS+. Abstract Enhancer of Zeste Homolog 2 locus is intensely over expressed in breast and prostate cancer and it’s been established that its promoter inhibition by p53 has led to reduced cell proliferation and invasion (Bracken, 2003; Xiao, 2011). Objective is to clone a forward orientated EZH2 insert into a his-tagged pbluescript. Cloning EZH2 into a histidine-tagged

NEOPLASIA Presented by Dr Abudu Emmanuel Kunle (MBBS, M.Sc, FMCPath) Senior Lecturer and Consultant Histopathologist University of Uyo Teaching Hospital,Uyo, Akwa- Ibom State, Nigeria. Neoplasia means the process of new growth whilst Neoplasm means a new growth. Sometimes, the parenchyma cells stimulate the formation of an abundant collagenous stroma, referred to as desmoplasia. Some tumours e.g. some cancers of breast are stony hard or scirrhous. Sarcomas have little connective tissue stroma and

progressive disease of the large and intermediate-sized arteries characterized by accumulation of lipids and fibrous elements which cause development of fatty lesions called atheromatous plaques on the inside surfaces of the arterial walls; and is the single most important contributor to this growing burden of cardiovascular disease. Studies on the pathophysiology of this disease has evolved over the past three decades, and a fusion of these views has led to the concept of the