Week 12 Discussion

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University of Maryland, University College *

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640

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Biology

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Oct 30, 2023

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docx

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Does genome editing have great potential? I enjoyed and learned a lot from every discussion post that I read in this class. I was very interested in the ethical issues of biotechnology, especially the possible risks associated with some of the genetic testing and the management of patient information as well as the debates against the use of embryonic stem cells for research purposes. It is obvious that new technologies give rise to ethical questions about the unknown risks and benefits. These questions become especially tricky and essential especially when considering something like human germline editing, which affects future generations who obviously can’t consent to the changes being made to their DNA. Even though it might be beneficial, some scientists have previously argued that germline editing can be used to prevent inherited diseases, but it would carry unacceptably serious safety, ethical, and social risks (Gaj, 2013). Therefore, researchers should always balance benefits and risks with individuals who are participating in research by giving them full informed consent. Personalized medicine was another interesting topic of discussion. I know that before selecting a first- line therapy for a patient, it is important to have all the information necessary to make an informed decision. Personalized medicine aims to streamline clinical decision-making by using available information including all biomarker test results as well as molecular testing which is performed via a broad panel-based approach line next-gene sequencing and then using that data to identify a targeted therapy for the patient. I think targeted therapies will eventually lead to better outcomes in patients with actionable biomarkers as well as give the doctors a better path forward for the patient. The most ethical issue would be equity and justice. For example, who would have access to genetic engineering or is it only affordable to those with financial resources given the likely expense of the procedure? If not, will it be covered by the medical insurance without discrimination against or hiking the premium for those covered? Reference Gaj, T., Gersbach, C. & Barbas, C. (2013). ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends in Biotechnology, 31(7), pp.397-405.
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