M2L2 ; D,Ingram ; Lab Report Qualitative Synthesis of Aspirin

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SUNY Empire State College *

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Chemistry

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Dec 6, 2023

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docx

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Qualitative Synthesis of Aspirin Dayna Ingram 10.22.2023
1 Purpose The purpose is to determine the chemical formula for aspirin synthesis, the first step is to make salicylic acid with the willow bark. Then, one can perform a full chemical analysis on the salicylic acid as well as acetylsalicylic acid using a pH test and iron chloride test. Aspirin can also be synthesized with willow bark extract. Procedure Gather materials -Acetic Acid -Iron Chloride -Salicylic Acid -Acetylsalicylic Acid -Ethanol -Willow bark -Well plate -Mini Spoon -pH Paper -Pipets -Stir Rod Label first two rows of Well plates A1-A6; B1-B6 Gather Salicylic Acid in the mini spoon for Well A1 Gather Acetylsalicylic Acid in the mini spoon for Well A2 Place Willow Bark in A6 Cover Willow Bark with Ethanol Let Willow Bark and Ethanol soak for 30 minutes. Place 15 drops of Ethanol to Well B1 and B2 Place 10 drops of Iron (III) Chloride to Well B3 Place 10 drops of Acetic Acid to Well B4 Use a blank piece of paper under Well Plate to notice any color changes Document all observations in the Data Table Gather 3 pipets label them “EtOH” ; “FeCl3” ; “AA” Using the EtOH Pipet to transfer 10 drops from Well B1 to Well A1and stir for a minute Place the Stir Rod on the pH paper to test the solution. Then clean the Stir Rod Using the EtOH pipet again, transfer 10 drops from Well B2 to Well A2 and repeat stirring and documenting pH © 2016 Carolina Biological Supply Company
2 Using the FeCl3 pipet transfer only one drop of Iron(III) Chloride from Well B3 to Well A1 and document in Data Table Next transfer one drop from B3 to A2 and record Data Using the EtOH pipet and transfer 10 drops from Well A6 to A3. Mix and test on pH paper and document observations. Using the FeCl3 pipet transfer one drop of Iron(III) Chloride from Well B3 to Well A3 and document observations. Using the EtOH pipet and transfer 10 drops from Well A6 to Well A4 Using the FeCl3 pipet transfer one drop from Well B3 to Well A4 Using the AA pipet transfer a few drops from Well B4 to A4 Using the Stir Rod dip in A4 and test on a new pH paper Document and record Data Experimental Data and Calculations Activity 1 Data Table pH Determination Well A1 Well A2 Well A3 Well A4 pH Strip Color Red/orange Light Orange Orange Deep Red pH 2 4 5 1 Iron Chloride Test Well A1 Well A2 Well A3 Well A4 Solution Color Purple Light Orange Green Light Orange Positive or Negative for Phenol? Positive Negative Positive Negative Photo Insert a picture of the well plate. © 2016 Carolina Biological Supply Company
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