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Qualitative Synthesis of Aspirin
Dayna Ingram
10.22.2023
1
Purpose
The purpose is to determine the chemical formula for aspirin synthesis, the
first step is to make salicylic acid with the willow bark. Then, one can perform
a full chemical analysis on the salicylic acid as well as acetylsalicylic acid
using a pH test and iron chloride test. Aspirin can also be synthesized with
willow bark extract.
Procedure
Gather materials
-Acetic Acid
-Iron Chloride
-Salicylic Acid
-Acetylsalicylic Acid
-Ethanol
-Willow bark
-Well plate
-Mini Spoon
-pH Paper
-Pipets
-Stir Rod
Label first two rows of Well plates A1-A6; B1-B6
Gather Salicylic Acid in the mini spoon for Well A1
Gather Acetylsalicylic Acid in the mini spoon for Well A2
Place Willow Bark in A6
Cover Willow Bark with Ethanol
Let Willow Bark and Ethanol soak for 30 minutes.
Place 15 drops of Ethanol to Well B1 and B2
Place 10 drops of Iron (III) Chloride to Well B3
Place 10 drops of Acetic Acid to Well B4
Use a blank piece of paper under Well Plate to notice any color changes
Document all observations in the Data Table
Gather 3 pipets label them “EtOH” ; “FeCl3” ; “AA”
Using the EtOH Pipet to transfer 10 drops from Well B1 to Well A1and stir for
a minute
Place the Stir Rod on the pH paper to test the solution. Then clean the Stir
Rod
Using the EtOH pipet again, transfer 10 drops from Well B2 to Well A2 and
repeat stirring and documenting pH
© 2016 Carolina Biological Supply Company
2
Using the FeCl3 pipet transfer only one drop of Iron(III) Chloride from Well B3
to Well A1 and document in Data Table
Next transfer one drop from B3 to A2 and record Data
Using the EtOH pipet and transfer 10 drops from Well A6 to A3. Mix and test
on pH paper and document observations.
Using the FeCl3 pipet transfer one drop of Iron(III) Chloride from Well B3 to
Well A3 and document observations.
Using the EtOH pipet and transfer 10 drops from Well A6 to Well A4
Using the FeCl3 pipet transfer one drop from Well B3 to Well A4
Using the AA pipet transfer a few drops from Well B4 to A4
Using the Stir Rod dip in A4 and test on a new pH paper
Document and record Data
Experimental Data and Calculations
Activity 1
Data Table
pH
Determination
Well A1
Well A2
Well A3
Well A4
pH Strip Color
Red/orange
Light
Orange
Orange
Deep Red
pH
2
4
5
1
Iron Chloride Test
Well A1
Well A2
Well A3
Well A4
Solution Color
Purple
Light
Orange
Green
Light
Orange
Positive or
Negative for
Phenol?
Positive
Negative
Positive
Negative
Photo
Insert a picture of the well plate.
© 2016 Carolina Biological Supply Company
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Related Questions
Natural goldenrod pigment is a yellow dye that changes to a bright red color in the presence of a basic solution and remains yellow in contact with an acidic or neutral solution. Peter is using goldenrod paper to test three solutions he prepared
Because Peter wants his message to be clearly visible in a red background at the end of his investigation, in what sequence should he use the solutions to paint the paper?
A
Paint first with lemon juice and then with tap water.
B
Paint first with laundry detergent and then with tap water.
C
Paint first with laundry detergent and then with lemon juice.
D
Paint first with lemon juice and then with laundry detergent.
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Constants | Periodic Table
2,2-Dimethylpropanoic (or pivalic) is a weak organic acid
that has a pungent odour. It's ester with vinyl alcohol are
used to ake polymers that are used as highly reflective
lacquers.
Part C
In Part A, a 20.00 mL aliquot of a 0.185 mol L-1 2,2-dimethylpropanoic acid solution was titrated to its equivalence point with 18.7 mL of
0.198 mol L-1 NaOH solution. At the equivalence point, all of the weak acid, 2,2-dimethylpropanoic acid, is converted to its weak
conjugate base, 2,2-dimethylpropanoate. What is the pH at this equivalence point?
O 5.030
9.005
O 6.987
2-2-dimethylpropanoic
acid
O 4.995
O 8.970
The Ka of 2,2-dimethylpropanoic acid is 9.33x10-6.
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Question: Comment on the solubility of the two dyes in water. In your answer consider intermolecular bonds and their relative strengths.
Solubility of dye C:
Solubility of dye D:
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What is the precipitant resulting from the following lab procedure?
Lab: Extraction of a Three Component MixtureIntroduction:Understanding how a molecule will react based on its properties is the core of organic chemistry.One of the easiest to understand “structure-activity” relations is acid/base chemistry. In addition, thechemistry and thinking process in acid/base chemistry can be extended to be the basis for many of thereactions that you will learn about in this class. This lab will take advantage of acid/base propertiesin order to separate compounds using liquid/liquid extraction techniques. The following compoundsare present in the sample that you will be given and need to be separated into their pure components.Benzoic Acid Ethyl-4-aminobenzoate 9-FluorenoneProcedure:In the main hood you will find the powdered mixture of the three compounds, BenzoicAcid, Ethyl-4-Amino Benzoate, and 9-Fluorenone. Add this mixture to a clean separatory(sep) funnel (be sure the stopcock and closed…
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13) Bromthymol blue (BTB) is a chemical indicator that is blue all alone. When combined with a basic
solution, it turns green as a solution becomes more acidic it turns yellow in an acidic solution. Fill in
what color you think bromthymol blue would be in each of the situations in the chart. If solution
color is given, simply provide a logical, possible pH value based on the outcomes. Fill in the missing
ions as well!
Situation
pH
BTB color
Ion present
Water directly out of tap
7.2
pH after exhaled air is blown through a straw into water for 5
5.1
H+
min.
14
pH after a snail has lived in water for three days
Very Yellow
pH with 2mL of bleach added to the water
Very Blue
5.0
pH with instant coffee added to the water
pH after an aquatic plant is grown in water for three days in
bright sunlight
Light Blue
OH-
14)Is BTB a chemical indicator?
15) What then does it "indicate"?
16) Based on the data above, why does drinking coffee cause stomach pain for some indivudals?
17) What effect does…
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Hi,
When vinegar is added to a solution of sodium bicarboneate, the mixture immediately begis to bubble furiously. As time passes, however, there is less and less bubbling. Explain why this happens.
Thank you,
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10:13
A) HNO₂
Which one of the following is a strong acid?
B) HF
C) HCIO4
Question 1 of 12
D) HC₂H3O2
Submit
Tap here or pull up for additional resources
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Assume that:
• Acid 1 is a stronger acid that Acid 2.
You prepare two separate solutions, using 1.0 mol of each acid and mixing it with 1.0 L of
pure water.
Determine which of the following statements is correct. Select all that apply.
O Multiple answers: Multiple answers are accepted for this question
Select one or more answers and submit. For keyboard navigation... SHOW MORE V
a
Acid 1 has a larger K value that Acid 2.
b
Acid 1 will generate a higher concentration of H,0* ions.
The solution prepared using Acid 1 will have a lower pH.
d.
Acid 1 will generate a higher concentration of A- ions.
e
The concentration of unreacted "HA" at equilibrium for the Acid 1 solution will be lower.
f
The pK value for Acid 1 is lower than the pK value for Acid 2.
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Part C – Acid–base and solubility equilibria
1. Rinse 4 regular size test tubes and a 10 mL measuring cylinder thoroughly with water. Number the test-tubes from 1 to 4 in a test tube rack.
2. Into each of test tubes 1 – 3 put a small amount of solid benzoic acid (put the same amount – about the size of a pea – in each test tube).
3. Add 2 mL (use the measuring cylinder) of water to tube 1 and shake to mix the contents.
4. Add 2 mL (measuring cylinder) of 2 M HNO3 to tube 2 and shake to mix the contents.
5. Rinse the measuring cylinder with water, then use it to add 2 mL of 2 M NaOH to tube 3 and shake for about 10 seconds to mix the contents. Rinse the measuring cylinder.
6. Pour about half of the solution from tube 3 into tube 4, than add 2 mL of 2 M HNO3 to tube 4.
7. Allow the test tubes to stand for 2 or 3 minutes then record the appearance of the mixtures in each test tube.
8. Answer the questions on the results page relating to this equilibrium system.
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Question 9:
30.0 mL of a 0.20 M solution of the weak base methylamine is titrated
with 0.10 M nitric acid (HNO3). The Kb of methylamine can be found
in Appendix I. Calculate the pH at each volume of base addition as
listed below and report your answer to two decimal places
The initial pH (after 0.0 mL of nitric acid addition) is
The pH after 10.0 mL of nitric acid addition is
The pH after 30.0 mL of nitric acid addition is
The pH after 60.0 mL of nitric acid addition is
The pH after 65.0 mL of nitric acid addition is
100
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Table 12.3 (data)
Substance
pH
Substance
pH
Substance
pH
Lemon Juice
Household ammonia
Baking soda
Orange Juice
Detergent (Laundry)
Aspirin
Milk
Detergent (dishwashing)
Buffered aspirin
Salivia
Table 12.4 (report)
Substance
pH
Substances
pH
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11:16 PM Tue Oct 12
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Objective Knowledge Check
Question 8
Caliyah
Complete the table below by deciding whether a precipitate forms when aqueous solutions A and B are mixed. If a precipitate will form, enter its empirical
formula in the last column.
Does a
precipitate form
when A and B
empirical
formula of
solution A
solution B
precipitate
are mixed?
ammonium nitrate
potassium acetate
O yes
no
potassium sulfide
silver nitrate
O yes
no
iron(II) chloride
zinc acetate
O yes O no
I Don't Know
Submit
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2)
1.
Februurg 2, 2022
Lyonel Tanis
CHM-0IL
Section: C16130)
Name:
Date:
Report Sheet: Characterization of a Weak Acid.
UNKNOWN NUMBER
A. Standardization of NaOH Solution
TRIAL
[HCI]
Volume
Moles
Moles
Volume
[NAOH]
HCI
NaOH
NaOH
24.65
25.75
0.1002
25.89
25.73
Average [NaOH].
B. Identification of the Unknown Acid
8.
Determination of Molecular Weight
TRIAL
[NaOH]
Volume
Moles
Moles
Grams
Molecula
Unknown
HOBN
Unknown
r Weight
(g/mol)
NaOH
0.2947
Lohe
24.07
1.
0.2943
2.
3
Average Molecular Weight
(g/mol)
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2- Weak base ionization constant
3- Constant effective solvation
product
4- All of the above
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STANDARDIZATION OF A SODIUM
HYDROXIDE SOLUTION
PRE-LABORATORY
EXPERIMENT 10
QUESTIONS
NAME
DATE
1. What is the purpose of this experiment?
2. A sample of KHP has a mass of 2.345 g is used for a titration, how many moles of KHP is this
sample?
3. How many moles of NaOH would be needed to reach the endpoint of this titration with sample of
KHP from the previous question?
4. If the initial volume of the NaOH in the burette was 0,50 mL
and the final volume is shown to the right, what is the volume of
NaOH used in this titration?
18
19
5. What is the concentration of the NaOH solution used in this titration?
EXPERIMENT 10
155
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percent will be too high
percent will be too low
no effect on the percent
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=
O ACIDS AND BASES
Identifying the major species in weak acid or weak base...
esc
The preparations of two aqueous solutions are described in the table below. For each solution, write the chemical formulas of the major species present at
equilibrium. You can leave out water itself.
0.7 mol of KOH is added to
1.0 L of a 0.7 M HCN
solution.
Write the chemical formulas of the species that will act as acids in the 'acids' row, the formulas of the species that will act as bases in the 'bases' row, and the
formulas of the species that will act as neither acids nor bases in the 'other' row.
You will find it useful to keep in mind that HCN is a weak acid.
0.13 mol of NaOH is added
to 1.0 L of a solution that is
1.5M in both HCN and
NaCN.
Explanation
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0 other:
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If salicylic acid dissociated into two particles when dissolved into myristic acid (it does not), would this change your calculated Kf value? Explain why. (Hint: look over your notes on the van’t Hoff factor, from lecture, for help.)
arrow_forward
Watch the ChemTour animation below on buffers before answering the following question.
BUFFERS
Introduction
A pH buffer is a solution that can minimize changes in pH when small amounts of acid or base are
added to it.
Control of pH is very important for chemical reactions in living systems. Our blood pH is about 7.4,
and changes of a few tenths of a pH unit either way can cause serious health consequences. The
blood has a buffer system to help regulate pH.
Death
Acidosis
Alkalosis
Death
6.6
6.8
7.0
7.2
7.4
7.6
7.8
8.0
Section 1 of 14
1st attempt
See Periodic Table
A 1.00 L solution contains 21.52 g of nitrous acid, HNO2. What mass of sodium nitrite, NaNO2, should be
added to it to make a buffer with a pH of 2.76? K, (HNO2) = 4.0 × 10-4.
X 143.5
Normal
国
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Watch the ChemTour animation below on buffers before answering the following question.
BUFFERS
Introduction
A pH buffer is a solution that can minimize changes in pH when small amounts of acid or base are
added to it.
Control of pH is very important for chemical reactions in living systems. Our blood pH is about 7.4,
and changes of a few tenths of a pH unit either way can cause serious health consequences. The
blood has a buffer system to help regulate pH.
Death
Acidosis
Alkalosis
Death
6.6
6.8
7.0
7.2
7.4
7.6
7.8
8.0
Section 1 of 14
2nd attempt
Feedback
See Periodic Table
See Hint
A 1.00 L solution contains 14.52 g of nitrous acid, HNO,. What mass of sodium nitrite, NaNO,, should be added to it to make a buffer
with a pH of 3.26? K, (HNO2) = 4.0 × 10-4.
* 8.79
Normal
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1. Calculate the theoretical molarity of 100ml of a 0.10 M NaOH solution.
2. Calculate the actual molarity of the NaOH solution that you prepared.
3. Calculate the percent error between the two NaOH values above.
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